Sökning: "Atorvastatin"

Visar resultat 16 - 18 av 18 avhandlingar innehållade ordet Atorvastatin.

  1. 16. Macrophage expression of VEGF and VEGFR-1. Potential involvement in atherogenesis

    Författare :Linda Salomonsson; Göteborgs universitet; []
    Nyckelord :atherosclerosis; macrophages; oxLDL; statins; VEGF; VEGFR-1;

    Sammanfattning : The vascular endothelial growth factor (VEGF) family is a group of proteins which contributes to both neovascularisation and inflammation. Elevated levels of VEGF have been found in subjects with atherosclerosis and correlate to several cardiovascular risk factors, e.g. hypertension and hyperlipidemia. LÄS MER

  3. 17. CYP3A and lipids in health and disease : in females and males

    Författare :Helena Bergström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sex and gender differences in the pharmacokinetics-and dynamics of drugs, have been known for centuries. Women have been regarded as different - a 70 kg male has been the norm in medicine. LÄS MER

  4. 18. Studies on cholesterol homeostasis by modulation of lipoproteins and bile acids

    Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholesterol; lipoproteins; bile acids; cholestyramine; chenodeoxycholic acid; CYP7A1; HNF4alpha; PCSK9; hepatocytes; ethanol; atherosclerosis; ApoE; thyroid hormone receptor;

    Sammanfattning : Excess plasma cholesterol, in particular high levels of LDL cholesterol, is a major risk factor for the development of atherosclerosis. The liver has a central role in the regulation of cholesterol metabolism: i) a major part of the cholesterol present in the body is synthesized in the liver; ii) the level of plasma lipoproteins is regulated by liver uptake and secretion of these particles and iii) the liver is essential for elimination of cholesterol from the body as such or by its conversion into bile acids. LÄS MER