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Visar resultat 1 - 5 av 14 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Cytokine studies in the generation and treatment of IgE-mediated allergy

    Författare :Ankie Söderlund; Huub Savelkoul; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytokines; Hypersensitivity; Allergy; Allergi; immunologi; Immunology;

    Sammanfattning : So called Th2 cytokines, such as IL-4 and IL-13 are responsible for the formation of IgE antibodies, the effector antibody in atopic allergy. Cytokines of Th1 type, for example IFN-g, inhibit these responses. This thesis describes work aimed at elucidating the cytokine production underlying IgE-mediated allergy. LÄS MER

  3. 2. Early-life gut microbiota and breast milk oligosaccharides in relation to childhood immune maturation and allergy

    Författare :Ylva Margareta Sjögren; Eva Sverremark-Ekström; Outi Vaarala; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergy; infant; gut microbiota; human milk oligosaccharides; Bifidobacterium; Lactobacillus; Bacteroides fragilis; Clostridium difficile; family size; secretory IgA; toll like receptor; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Atopic allergy is the most common chronic disease among children in the developed world. This high prevalence could be associated with low microbial exposure. The early gut microbiota appears to be important for immune maturation. LÄS MER

  4. 3. Early infant gut flora and neutral oligosaccharides in colostrum in relation to allergy development in children

    Författare :Ylva Sjögren; Eva Sverremark-Ekström; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Immunology; Immunologi;

    Sammanfattning : Today, atopic allergy is the most common chronic disease among children in the developed world. The increase in allergy prevalence during the past decades in these countries might be associated with lower microbial exposure. LÄS MER

  5. 4. Early childhood thymectomy - impact on immune function

    Författare :Judith Gudmundsdottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Immunologi; Thymus; Pediatric cardiac surgery; Congenital heart defect;

    Sammanfattning : Introduction: The thymus is the site of T cell maturation. Children born with a congenital heart defect often endure surgery early in life, and during surgery their thymus is routinely removed, as it blocks the surgeons access to the heart. LÄS MER

  7. 5. Experimental and Clinical Studies of SLPI, with Special Reference to IgE-Mediated Allergic Reactions

    Författare :Ulla Westin; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ hybridisation; immunohistochemistry; allergic rhinitis; atopic subjects; IgE-mediated histamine release; mast cell proteases; plasma protease inhibitors; SLPI; human leukocyte proteases; Immunology; serology; transplantation; Immunologi; serologi;

    Sammanfattning : In this study we demonstrated the production of SLPI (Secretory Leukocyte Protease Inhibitor) in serous glands in the nasal mucosa. We have shown that the pattern of the expression of mRNA corresponds to the encoded protein. The encoded protein was detected by immunohistochemical methods and mRNA was discovered by in situ hybridisation. LÄS MER