Sökning: "Asymmetric application"

Visar resultat 1 - 5 av 89 avhandlingar innehållade orden Asymmetric application.

  1. 1. Novel Pincer Complex-Catalyzed Transformations : Including Asymmetric Catalysis

    Författare :Juhanes Aydin; Kálmán J. Szabó; Oleg V. Ozerov; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pincer; palladium; catalysis; chiral; asymmetric; palladium IV; allylation; aldol; aminoacid; C-H functionalization; cross-coupling; homoallylic; heck reaction; tridentate ligand; Chemistry; Kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis is focused on the development of new pincer complex-catalyzed transformations. Optimization of the catalytic properties (fine-tuning) was directed to increase the catalytic activity as well as the chemo-, stereo- and enantioselectivity of the complexes. LÄS MER

  3. 2. Asymmetric Oligothiophenes : Chemical Evolution of Multimodal Amyloid Ligands

    Författare :Leif B.G. Johansson; Peter Nilsson; Peter Konradsson; Mikael Elofsson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Luminescent conjugated polymers (LCPs) and luminescent conjugated oligothiophenes (LCOs) can be used as molecular probes to study diseases associated with protein aggregation. The conventionally used dyes to study and detect protein aggregates, denoted amyloid, have been Congo red (CR) and Thioflavin T (ThT). LÄS MER

  4. 3. Development and application of new chiral -amino alcohols in synthesis and catalysis : Use of 2-azanorboryl-3-methanols as common intermediates in synthesis and catalysis

    Författare :Pedro Pinho; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Asymmetric synthesis; hetero-Diels-Alder reactions; chiral cyclopentyl-amines; chiral ligands and catalysts; amino alcohols; asymmetric reductions; ruthenium transfer hydrogenation; oxazaborolidines; asymmetric additions; dialkylzinc reagents; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : The development and application of unnatural amino alcohols,prepared via hetero-Diels-Alder reactions,in synthesis and catalysis is described.The studies are concerned with the [i]scope of the hetero-Diels-Alder reaction and preparation of important intermediates in the synthesis of antiviral agents,[ii ]application of amino alcohols in the ruthenium transfer hydrogenation of ketones,[iii ]use of similar precursors in the in situ generation of oxazaborolidines for reduction of ketones,and [iv] development and application of new chiral auxiliaries for dialkylzinc additions to activated imines, respectively. LÄS MER

  5. 4. Enzyme- and Transition Metal-Catalyzed Asymmetric Transformations : Application of Enzymatic (D)KR in Enantioselective Synthesis

    Författare :Richard Lihammar; Jan-Erling Bäckvall; Wolfgang Kroutil; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dynamic Kinetic Resolution; Kinetic Resolution; Enzyme Catalysis; Asymmetric Synthesis; organisk kemi; Organic Chemistry;

    Sammanfattning : Dynamic kinetic resolution (DKR) is a powerful method for obtaining compounds with high optical purity. The process relies on the combination of a kinetic resolution with an in situ racemization. LÄS MER

  7. 5. Asymmetric Cellular Microenvironments

    Författare :Susanna Rydholm; Hjalmar Brismar; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics; Fysik;

    Sammanfattning : This thesis presents methods to combine 3D cell culture, microfluidics and gradients on a controlled cellular scale. 3D cultures in biological extracellular matrix gels or synthetic gels bridge the gap between organ-tissue cultures and traditional 2D cultures. LÄS MER