Sökning: "Asymmetric Horner-Wadsworth-Emmons"

Hittade 4 avhandlingar innehållade orden Asymmetric Horner-Wadsworth-Emmons.

1. 1. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis

   Författare :Daniel Strand; Tobias Rein; Viresh Rawal; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antitumor agents; Asymmetric Horner-Wadsworth-Emmons; Desymmetrization; Metal-catalyzed olefination; Mucocin; Palladium-catalyzed allylic substitution; Parallel kinetic resolution; Pyranicin; Pyragonicin; Rhenium; Stereoconvergent synthesis; Stereodivergent synthesis; Stereoselective synthesis; Tetrahydropyran; Wittig reaction; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. LÄS MER

3. 2. Synthetic approaches to chiral tetrahydropyran and tetrahydrofuran derivatives by use of asymmetric Horner-Wadsworth-Emmons reactions

   Författare :Lauri Vares; KTH; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER

4. 3. Synthesis of aromatic bis- and tris(amino acids) and chiral dendrimers

   Författare :Andreas Ritzén; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; Organic chemistry; HWE reaction; asymmetric hydrogenation; Heck reaction; Amino acids; chiral dendrimers;

   Sammanfattning : A number of protected aromatic bis- and tris(amino acids) have been synthesised by catalytic asymmetric hydrogenation of the corresponding didehydroamino acid derivatives. The didehydroamino acid derivatives were prepared either by a Heck coupling of a 2-amidoacrylate with an aryl dihalide, or by Horner-Wadsworth-Emmons olefination of aromatic aldehydes with phosphonylglycine reagents. LÄS MER

5. 4. Non Natural Aromatic Amino Acids Applications in cage-construction, metal ion coordination and asymmetric catalysis

   Författare :Ruxandra Ionescu; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diethylzinc additions.; spectroscopy; metal ion coordination; cage-like compounds; Amino acids; C3-symmetry; Organic chemistry; Organisk kemi;

   Sammanfattning : Aromatic non-natural amino acids, the outstanding feature of which was the presence of several arms, were synthesised and their properties investigated. The amino acids were synthesised following a standard procedure starting with a Horner-Wadsworth-Emmons or a Heck reaction, which provided didehydroamino acids. LÄS MER