Sökning: "Astrocytes"

Visar resultat 6 - 10 av 242 avhandlingar innehållade ordet Astrocytes.

  1. 6. The effect of astrocytes and reactive gliosis on neurogenesis and astrogenesis in mice

    Författare :Åsa Widestrand; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astrocytes; intermediate filaments; neural stem cells; neurogenesis; astrogenesis; hippocampus;

    Sammanfattning : Astrocytes are the most common cell type in mammalian central nervous system (CNS). Glial fibrillary acidic protein (GFAP) and vimentin constitute intermediate filaments (known also as nanofilaments), a part of the cytoskeleton, in astrocytes. LÄS MER

  3. 7. Role of intermediate filaments and expression of GFAP and S-100 in astrocytes

    Författare :Mei Ding; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Astrocytes; Gliosis; Kainic acid; Transgenic mouse; S-100; GFAP; Vimentin; RVD regulatory volume decrease ; Taurine; Glutamine; Ascorbate; Glucose;

    Sammanfattning : Astrocytes participate in a variety of important physiologic and pathologic processes in the central nervous system (CNS). One of the most remarkable characteristics of astrocytes is their vigorous response to CNS injuries. LÄS MER

  4. 8. Astrocytes as Cellular Vehicles in Ex Vivo Gene Therapy Studies to the Rat Brain

    Författare :Cecilia Ericson; CNS Genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; Lentivirus; Transplantation; CNS; Astrocytes;

    Sammanfattning : Neurodegenerative disorders are characterized by a progressive cell-death in the brain, and loss of different functions in the patient. Today, there are no cures for any of the various diseases. Parkinson's disease is a neurodegenerative disorder with a prevalence of 0. LÄS MER

  5. 9. CRISPR/Cas9-based therapies and the role of astrocytes in Alzheimer’s disease and Parkinson’s disease

    Författare :Evangelos Konstantinidis; Martin Ingelsson; Anna Erlandsson; Vilmantas Giedraitis; Magnus Essand; Harald Steiner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Parkinson s disease; gene editing; CRISPR Cas9; amyloid-beta; astrocytes; neurons; iPSCs; electrophysiology;

    Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative disorders. Whereas the AD brain features plaques of amyloid-beta (Aβ) and neurofibrillary tangles of tau, the PD brain is characterized by Lewy bodies and Lewy neurites containing α-synuclein (αSyn). LÄS MER

  7. 10. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

    Författare :Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
    Nyckelord :Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER