Sökning: "Astrid Gruber"

Hittade 1 avhandling innehållade orden Astrid Gruber.

1. 1. Experimental studies on multidrug resistance in human leukaemia : role of cellular heterogeneity for daunorubicin kinetics

   Författare :Eva Knaust; Curt Peterson; Anna Porwit-MacDonald; Astrid Gruber; Christer Paul; Linköpings universitet; []
   Nyckelord :Acute myeloid leukaemia; heterogeneity; multidrug resistance. transport kinetics flow cytometry; gene expression; mdr1; mrp; lrp; apoptosis. bcl-2; p53; MEDICINE; MEDICIN;

   Sammanfattning : Cellular resistance to chemotherapy is a major cause of treatment failure in acute myeloid leukaemia (AML) and still the majority of the patients die from their disease. Drug resistance 1s multifactorial, the most studied mechanism being multidrug resistance (MDR), mediated by the P-glycoprotein (Pgp). LÄS MER