Sökning: "Astrid Gräslund"
Visar resultat 21 - 24 av 24 avhandlingar innehållade orden Astrid Gräslund.
21. NMR studies on interactions between the amyloid β peptide and selected molecules
Sammanfattning : Alzheimer’s disease is an incurable neurodegenerative disorder linked to the amyloid β (Aβ) peptide, a 38-43 residue peptide. The detailed molecular disease mechanism(s) is (are) unknown, but oligomeric Aβ structures are proposed to be involved. LÄS MER
22. Exploring amino-acid radicals and quinone redox chemistry in model proteins
Sammanfattning : Amino-acid radical enzymes have been studied extensively for 30 years but the experimental barriers to determine the thermodynamic properties of their key radical cofactors are so challenging that only a handful of reports exist in the literature. This is a major drawback when trying to understand the long-range radical transfer and/or catalytic mechanisms of this important family of enzymes. LÄS MER
23. Biophysical investigations of ribonucleotide reductase : Activation and inhibition mechanisms
Sammanfattning : Ribonucleotide reductase (RNR) is the enzyme responsible for de novo synthesis of deoxyribonucleotides, needed for both synthesis and repair of cellular DNA. The RNRs known so far are divided into three distinct classes; I, II and III. The conventional class I enzyme is composed of two separate subunits. LÄS MER
24. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization
Sammanfattning : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. LÄS MER