Sökning: "Asna-1"

Hittade 4 avhandlingar innehållade ordet Asna-1.

1. 1. Insulin secretion and ASNA-1-dependent function of the endoplasmic reticulum in C. elegans

   Författare :Ola Billing; Gautam Kao; Jussi Jäntti; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell research; cellforskning; genetik; Genetics;

   Sammanfattning : ASNA1 is a well-conserved ATPase involved in a wide range of functions, including cisplatin resistance, growth control, insulin secretion and targeting of tail-anchored (TA) proteins to membranes. It is a positive regulator of insulin secretion both in the roundworm Caenorhabditis elegans and in humans. LÄS MER

3. 2. New modifiers of insulin signalling identified by interaction screens with ASNA-1 in C. elegans

   Författare :Balasubramanian Natarajan; Peter Naredi; Richard Padgett; Umeå universitet; []
   Nyckelord :Insulin; C. elegans; ASNA1; Cisplatin; GRP94; unfolded protein response; SMN1; Developmental Biology; miljömedicinsk utvecklingsbiologi;

   Sammanfattning : Background: Insulin is a hormone released by the pancreatic beta cells in response to elevated levels of nutrients in the blood. Insulin triggers the uptake of glucose, fatty acids and amino acids into the liver, adipose tissue and muscles. LÄS MER

4. 3. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells

   Författare :Oskar Hemmingsson; Peter Naredi; Mef Nilbert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ASNA1; Cisplatin; C. elegans; Drug resistance; Apoptosis; Surgery; Kirurgi; Oncology; Onkologi; Surgery; kirurgi; Oncology; onkologi; cellforskning; cell research;

   Sammanfattning : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. LÄS MER

5. 4. Signaling pathways and novel genetic factors involved in modulation of cisplatin response in C. elegans

   Författare :Dorota Raj; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C. elegans; cisplatin; cancer; stress; immunity; post-mitotic; tail-anchored proteins;

   Sammanfattning : Cancer is a major cause of mortality throughout the world. Despite the effort of the scientific community, plenty remains to understand about the biology or genetics of cancer. In solid tumors often as many as 90-99% of all cells are non-dividing. LÄS MER