Sökning: "Articular cartilage"

Visar resultat 21 - 25 av 67 avhandlingar innehållade orden Articular cartilage.

  1. 21. Joint disease biomarkers - discovery and application

    Författare :Dovilė Sinkevičiūtė; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Psoriatic arthritis; cartilage; Proteomics; Biomarkers; ELISA; Tissue culture; Extracellular matrix ECM ;

    Sammanfattning : Dysregulated cartilage homeostasis, articular cartilage degradation and abnormal bone remodeling are common denominators in joint disease and can lead to severe disability for the patients. The molecular pathways behind the disease pathology can overlap across different joint diseases. LÄS MER

  3. 22. Studies on chondroadherin-an extracellular matrix leucine-rich repeat protein

    Författare :Christina Wenglén; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; COMP; SLRP; ECM; collagen; cartilage; chondroadherin;

    Sammanfattning : This thesis describes chondroadherin, one of the leucine-rich repeat proteins in the extracellular matrix (ECM) of cartilage. Chondroadherin defines a subgroup of its own by not having an N-terminal extension, having a different cysteine pattern and by being devoid of carbohydrate substitutions. LÄS MER

  4. 23. Chondrocyte-matrix interactions: with emphasis on the collagen binding integrin a10ß1

    Författare :Lisbet Camper; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; Skeleton; chondrocyte; integrin; cartilage; chondroadherin; collagen; Biochemistry; metabolism; Biokemi; reumatologi; muskelsystem; Skelett; rheumatology locomotion;

    Sammanfattning : The work in this thesis has been focused on chondrocyte integrins and their interaction with the matrix proteins chondroadherin (CHAD) and collagen type II (CII). Affinity purification of CHAD-binding proteins from chondrocyte lysate, followed by immunoprecipitation of EDTA-eluted material identified alpha2beta1 as a CHAD-binding integrin. LÄS MER

  5. 24. Proteomics of the human meniscus in health and osteoarthritis

    Författare :Elin Folkesson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Knee; OSTEOARTHRITIS; Knee; Meniscus; PROTEOMICS; microstructure; articular cartilage;

    Sammanfattning : Introduction: Osteoarthritis (OA) is one of the most common causes of knee pain, and the most common form ofarthritis. It causes pain and disability, and there is currently no cure. Recent research in knee OA highlights therole of the meniscus in OA pathology. LÄS MER

  7. 25. Finger Joint Reconstruction with Rib Perichondrium

    Författare :Daniel Muder; Torbjörn Vedung; Nils Hailer; Ola Nilsson; Simon Farnebo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; finger joint; reconstruction; cartilage; transplantation; osteoarthritis; Orthopaedics; Ortopedi;

    Sammanfattning : Difficulties in repairing and reconstructing articular cartilage damaged by trauma or disease remain unsolved and are one of the major challenges confronting orthopedic and hand surgeons in their clinical work. Relevant research has not adequately described the long-term clinical results, nor has it made a direct comparison to implant surgery after finger joint reconstruction with rib perichondrium. LÄS MER