Sökning: "Artesunate"
Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet Artesunate.
1. In vitro and in vivo studies of artemisinin endoperoxides
Sammanfattning : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. LÄS MER
2. Plasmodium falciparum resistance to amodiaquine in monotherapy and in combination therapy with artesunate
Sammanfattning : In response to the increasing resistance to antimalarial monotherapies, artemisinin basedcombination therapy (ACT) is now recommended as first line therapy against uncomplicatedPlasmodium falciparum malaria. However, the choice of partner drug to artemisinin (ART) iscritical for ACT efficacy to endure. LÄS MER
3. Search for genetic determinants of Plasmodium falciparum malaria drug resistance in vitro and in vivo
Sammanfattning : Malaria remains the most deadly disease in the world with nearly 627 000 deaths and more than 200 million new clinical cases every year, the large majority occurring in sub Saharan Africa children aged < 5 years. This represents anyway a significant decrease as compared with the situation in the start of the Millennium. LÄS MER
4. Managing malaria in under-fives : prompt access, adherence to treatment and referral in rural Tanzania
Sammanfattning : Background: Nearly a million people die of malaria each year, the majority are children in rural African settings. These deaths could be reduced if children had prompt access to artemisinin-based combination therapy (ACTs), demonstrated adherence to treatment and to referral advice for severe malaria. LÄS MER
5. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy
Sammanfattning : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. LÄS MER