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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Exploiting Drosophila as a model system for studying anaplastic lymphoma kinase in vivo

   Författare :Therese Eriksson; Ruth Palmer; Stefan Thor; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; Receptor tyrosine kinase; Jeb; neuroblastoma; actin polymerization; Wasp; Scar; Vrp1; Arp2 3; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : Anaplastic Lymphoma Kinase (ALK) is a Receptor Tyrosine Kinase (RTK) and an oncogene associated with several human diseases, but its normal function in humans and other vertebrates is unclear. Drosophila melanogaster has an ALK homolog, demonstrating that the RTK has been conserved throughout evolution. LÄS MER

3. 2. Neutrophil and endothelial cell-mediated inflammation in abdominal sepsis

   Författare :Zhiyi Ding; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; lung; neutrophil; endothelial cell; neutrophil extracellular traps; inflammation; capillary; post capillary venules; cytoskeleton; RNAseq;

   Sammanfattning : Sepsis is defined as a life-threatening condition caused by a dysregulated host response to infection. Neutrophils are themost abundant innate immune cells of the body and play a key role in septic pathogenesis. LÄS MER

4. 3. Role of PAK4 in pancreas development and breast cancer

   Författare :Miao Zhao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : PAK4 is a Rho GTPase-regulated serine/threonine kinase that possesses critical functions in embryonic, neuronal and vascular development, immune defense and cancer. Constitutive PAK4 depletion causes embryonic lethality and mice with conditional PAK4 gene depletion in the heart and in the central nervous system displayed serious organ defects. LÄS MER

5. 4. Elements in regulation of the microfilament system

   Författare :Louise Hillberg; Uno Lindberg; Theresia Stradal; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell motility; microfilament system; actin; tropomyosin; Cell and molecular biology; Cell- och molekylärbiologi; Cell Biology; cellbiologi;

   Sammanfattning : This thesis deals with cell motility. The process of rapid actin polymerization in the lamellipodium of a migrating cell is responsible for its protrusion. Studies have been made on some of the elements behind this event and special interest has been focused on the protein tropomyosin. LÄS MER

7. 5. Cell Behavior and the Role of Profilin

   Författare :Yu Li; Roger Karlsson; Christophe Ampe; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; Cellbiologi; cellbiologi; Cellbiology;

   Sammanfattning : Profilin is a key regulator of the microfilament system. It binds to actin monomers in a 1:1 complex, forming the profilin:actin complex, which is the major precursor of actin for filament formation in vivo. The distribution of profilin has been studied in a variety of cells. It is present not only in the cytoplasm but also in the nucleus. LÄS MER