Sökning: "ApoB"

Visar resultat 6 - 10 av 57 avhandlingar innehållade ordet ApoB.

  1. 6. The involvement of INSIGs, DGAT1 and APOB in human lipid metabolism

    Författare :Sergey Krapivner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is a complex pathophysiological condition characterized by lipid accumulation in the vascular wall. These lipids are derived from the lipoproteins present in the circulation. LÄS MER

  3. 7. Studies on the atherogenicity of apoB-containing lipoproteins in type 2 diabetes

    Författare :Camilla Pettersson; Göteborgs universitet; []
    Nyckelord :Type 2 diabetes; metabolic syndrome; atherosclerosis; VLDL; LDL; secretory phospholipase A2 group V; inflammation; complement; apolipoprotein; lysozyme;

    Sammanfattning : Type 2 diabetes (T2D) and the metabolic syndrome (MetS), two conditions that are rapidly increasing in prevalence, as well as the dyslipoproteinemia and subclinical inflammation characteristic for these conditions, are associated with an increased risk for developing and dying of cardiovascular disease (CVD). The aim of this thesis was to investigate possible atherogenic properties of very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) in T2D and MetS. LÄS MER

  4. 8. Studies on lipoprotein metabolism and atherogenesis

    Författare :Katharina Slätis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ApoA1; ApoB; ApoE; atherosclerosis; bile acids; cholic acid; cholesterol; cholesterol absorption; CYP7A1; CYP8B1; dexamethasone; GC-1; PAI-1; thyroid hormone receptor; very low density lipoprotein receptor;

    Sammanfattning : Atherosclerosis is the primary cause of cardiovascular events such as angina pectoris and myocardial infarction, which together with stroke are responsible for around 50% of all deaths in the United States and Europe. Usually atherosclerosis develops over several decades and leads to a progressive narrowing of arterial vessels. LÄS MER

  5. 9. Growth hormone and PPARa in the regulation of lipoprotein metabolism

    Författare :Daniel Lindén; Göteborgs universitet; []
    Nyckelord :growth hormone; insulin; fatty acids; PPARa; apolipoprotein B; VLDL; mRNA editing;

    Sammanfattning : In humans, apolipoprotein B (apoB)-100 is produced in the liver and apoB-48 is formed in the intestine. In the rat, however, the two forms of apoB are produced in the liver, leading to the formation of VLDL consisting of either apoB-48 or apoB-100. LÄS MER

  7. 10. Studies on the assembly and secretion of apolipoprotein B containing lipoproteins

    Författare :Karin Lindberg; Göteborgs universitet; []
    Nyckelord :apolipoprotein B; lipoprotein; lipoprotein biosynthesis; Brefeldin A; microsomal triglyceride transfer protein; liver fatty acid binding protein;

    Sammanfattning : Lipoproteins are water-soluble particles of lipids and proteins, which deliver water-insoluble lipids from intestine or liver to target tissues where the lipids are used as fuel or storage. Lipoproteins consist of a core of hydrophobic lipids surrounded by an amphipatic monolayer of polar lipids and specific proteins, apolipoproteins. LÄS MER