Sökning: "ApcMin mouse"

Hittade 5 avhandlingar innehållade orden ApcMin mouse.

  1. 1. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer

    Författare :Zhiyuan V. Zou; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; ApcMin mouse;

    Sammanfattning : Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or somatic mutations in the APC gene. LÄS MER

  3. 2. Natural killer T (NKT) lymphocytes regulate of intestinal tumor immunity

    Författare :Ying Wang; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NKT lymphocyte; intestinal tumor; CD1d; colrectal cancer; immunoregulation; α-gagactosylceramide;

    Sammanfattning : CD1d-restricted natural killer T (NKT) lymphocytes are known as potent early regulatory cells of immune responses, acting as a bridge between innate and adaptive immunity. While invariant NKT (iNKT) cells have a protective role in many tumor models, their ability to promote intestinal inflammation, known to enhance intestinal cancer, raised the question if they would be protective in intestinal tumor development. LÄS MER

  4. 3. The role of CysLT1R in animal models of colorectal cancer

    Författare :Sayeh Savari; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. LÄS MER

  5. 4. Pathophysiological impact of targeting the ROS-p53 axis

    Författare :Volkan I. Sayin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antioxidants; Cancer; p53; ROS; atherosclerosis;

    Sammanfattning : The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. LÄS MER

  7. 5. Inflammation-associated genes and genetic variations in colorectal cancer

    Författare :Nils Elander; Peter Söderkvist; Karin Fransén; Mef Nilbert; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Colorectal cancer is a major cause of morbidity and mortality around the world, each year affecting about one million individuals worldwide. The disease is characterized by an accumulation of genetic alterations, and a sequence of events leading to the development of an invasive and metastasising tumour. LÄS MER