Sökning: "Antithrombin"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet Antithrombin.

  1. 1. Development of Methods for Measuring Protein C Inhibitor and Antithrombin: Use of Monoclonal Antibodies against the Reactive Center Loop-Inserted Forms of the Serpins

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Margareta Kjellberg; [2007]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; monoclonal antibody; latent antithrombin; immunoassay; cleaved PCI; cleaved antithrombin; Antithrombin; APC-PCI complex;

    Sammanfattning : Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. LÄS MER

  2. 2. The Plasma Contact System New Functional Insights from a Hemostatic and Thrombotic Perspective

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jennie Bäck; Bo Nilsson; Kristina Nilsson Ekdahl; Ulla Hedner; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Contact activation; factor XII; platelets; coagulation; antithrombin; C1 inhibitor; hemostasis; biomarkers; vascular disease.; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : The physiological role of the plasma contact system still remains a partial enigma. The aim of the presented work was to expand our understanding of the plasma contact system, focusing on its physiological activation and function, principally from a hemostatic perspective. It also explored contact system activation under pathological conditions. LÄS MER

  3. 3. Regulation of Angiogenesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Helena Larsson; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; angiogenesis; anti-angiogenesis; endostatin; latent antithrombin; prelatent antithrombin; Crk; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik; Pathology; patologi;

    Sammanfattning : Angiogenesis is the formation of new blood vessels from pre-existing ones. New blood vessel formation is fundamental in processes such as reproduction, embryonic development and wound healing. Growth of neoplasms is accompanied by increased angiogenesis. This thesis describes cellular and molecular mechanisms of importance for angiogenesis. LÄS MER

  4. 4. Coagulation disturbances in the critically ill patient with special reference to prediction of outcome

    Detta är en avhandling från Department of Coagulation Disorders and Department of Anaesthesiology and Intensive Care, Malmö University Hospital, Lund University, Malmö, Sweden

    Författare :Gunnar Nilsson; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; protein C; mortality; intensive care; health economics; global haemostatic tests; blood coagulation disorders; APC-PCI complex; abdominal aortic aneurysm operation; antithrombin; Medicin människa och djur ;

    Sammanfattning : Critically ill patients in intensive care units (ICU) often have coagulation disturbances. Clinical manifestations such as thromboembolism and/or bleeding may result from activation and consumption of coagulation factors and inhibitors. Disseminated intravascular coagulation (DIC) is a severe condition with an often-poor prognosis. LÄS MER

  5. 5. Experimental studies on thrombin inhibition in acute- and chronic models of vessel wall injury

    Detta är en avhandling från Göteborg

    Författare :Fredrik Scherstén; Göteborgs universitet.; Gothenburg University.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; animal model; antithrombin; fibrinogen; histomorphology; melagatran; percutaneous coronary intervention; platelets; restenosis; stent; thrombin inhibition; thrombosis;

    Sammanfattning : Background: The number of percutaneous coronary interventions (PCI) performed worldwide has increased dramatically during the last decade. Complication rates have decreased over time, however the restenosis phenomenon remains an unsolved issue. Thrombin is the key regulator in the pro-coagulant state following PCI. LÄS MER