Sökning: "Antimalarial"
Visar resultat 1 - 5 av 57 avhandlingar innehållade ordet Antimalarial.
1. Organometallic complexes with antimalarial properties
Sammanfattning : Malaria is a serious disease that causes around 800 000 deaths per year. Current malaria control efforts are hampered by the widespread resistance to common antimalarial drugs, such as the 4-aminoquinoline derivative called chloroquine. LÄS MER
2. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids
Sammanfattning : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. LÄS MER
3. Development of field-adapted analytical methods for the determination of new antimalarial drugs in biological fluids
Sammanfattning : .... LÄS MER
4. Modelling and Simulation to Improve Antimalarial Therapy
Sammanfattning : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. LÄS MER
5. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy
Sammanfattning : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. LÄS MER