Sökning: "Antibodies"

Visar resultat 11 - 15 av 1733 avhandlingar innehållade ordet Antibodies.

1. 11. Calcium-dependent Affinity Domains for the Purification of Antibodies and Antibody Fragments

   Författare :Julia Scheffel; Sophia Hober; Alois Jungbauer; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antibodies; Antibody fragments; Biomanufacturing; Protein purification; Protein engineering; Protein A; ZCa; Calcium; Mild elution; Bioteknologi; Biotechnology;

   Sammanfattning : Antibodies are essential proteins in both our bodies and biotechnological research, and hold outstanding therapeutic value. The market for antibody-based therapeutics has grown exponentially during the last decades, owing to several advantages over small molecule drugs, such as fewer undesirable side effects associated with a higher target specificity. LÄS MER

3. 12. Development and application of monoclonal antibodies in studies of the human leukotriene B4 receptor, BLT1

   Författare :Annika Pettersson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serologi; transplantation; Immunologi; Immunology; serology; antibodies; BLT1; LTB4;

   Sammanfattning : Infection and inflammation are characterized by the release of chemotactic substances that activate cells of the immune system. One of these important mediators is LTB4, an arachidonic acid derivate that attracts e.g. monocytes and granulocytes to inflammatory sites and induces phagocytosis and degranulation. LÄS MER

4. 13. Immunomodulatory Therapy of Solid Tumors : With a Focus on Monoclonal Antibodies

   Författare :Linda Sandin; Thomas Tötterman; Mangsbo Sara; Fredrik Eriksson; Loskog Angelica; Ola Winqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ checkpoint blockade; antibody-mediated tumor immunotherapy; CTLA-4; CD40; monoclonal antibodies; experimental animal model; Fc gamma receptor; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Cancer, historically considered a genetic disease, is currently acknowledged to affect the whole body. Our immune system is one key player that can elicit a response against malignant cells but can also promote tumorigenesis. Tumors avoid immune recognition by creating a suppressive microenvironment and inducing tolerance. LÄS MER

5. 14. Validation of antibodies for protein profiling : A study using immunohistochemistry on tissue microarrays

   Författare :Linda Paavilainen; Fredrik Pontén; Ola Nilsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody validation; monospecific antibodies; protein profiling; immunohistochemistry; tissue microarrays; western blot; fixatives; Pathology; Patologi; Pathology; patologi;

   Sammanfattning : The field of proteomics has rapidly expanded due to the completion of the human genome sequence. This thesis validates affinity-purified monospecific antibodies of polyclonal origin, for protein profiling in a broad spectrum of normal tissues and cells. LÄS MER

7. 15. Avian antibodies applied in particle enhanced turbidimetric immunoassay : Developement of serum/plasma calprotectin immunoassay and its clinical performance as a marker for bacterial infections

   Författare :Tom Nilsen; Anders Larsson; Bjørn Steen Skålhegg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sepsis; avian antibodies; calprotectin antigen; particle enhanced turbidimetric immunoassay.; Clinical Chemistry; Klinisk kemi;

   Sammanfattning : Calprotectin is a cytosolic protein in the granulocytes, consisting of S100A8 and S100A9. On the site of inflammation, the neutrophils release the cytosol as an inflammatory response. The circulating calprotectin concentration increases and can therefore be used as marker for neutrophil activation and inflammation. LÄS MER