Sökning: "Antibiotics"

Visar resultat 6 - 10 av 547 avhandlingar innehållade ordet Antibiotics.

  1. 6. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Författare :Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER

  3. 7. Antibiotics use in relation to colorectal cancer risk, survival and postoperative complications

    Författare :Sai San Moon Lu; Bethany van Guelpen; Sophia Harlid; Jonas Ludvigsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; antibiotics; gut microbiome; dysbiosis; cancer-specific survival; surgical site infections; anastomotic leakage; register-based epidemiology; Cancer Epidemiology; cancerepidemiologi; Cancer Epidemiology; cancerepidemiologi; Oncology; onkologi; Surgery; kirurgi;

    Sammanfattning : Background: Growing evidence suggests that antibiotic-induced dysbiosis of gut microbiota potentially contributes to colorectal cancer development and oncological outcomes. However, the role of antibiotics in colorectal cancer incidence, survival and postoperative outcomes at a population level remains incompletely understood. LÄS MER

  4. 8. Monitoring anti-infectives and antibiotic resistance genes : with focus on analytical method development, effects of antibiotics and national perspectives

    Författare :Ghazanfar Ali Khan; Jerker Fick; Klaus Kümmerer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; method development; on-line solid phase extraction liquid chromatography mass spectrometry SPE LC-MS MS ; antibiotics; anti-infectives; constructed wetlands CWs ; denatured gradient gel electrophoresis DGGE ; percentage removal efficiency PRE ; shannon index; antibiotic resistance genes ARGs ; real-time polymerase chain reaction RT-PCR ; drug formulation facilities DFF ; wastewater; epidemiology; pandemic; influenza; compliance;

    Sammanfattning : Antibiotics are biologically active and are globally used in humans and animal medicine for treatment and in sub-therapeutic amounts as growth promoters in animal husbandry, aquaculture and agriculture. After excretion, inappropriate disposal and discharge from drug production facilities they enter into water bodies either as intact drugs, metabolites or transformed products. LÄS MER

  5. 9. External otitis and its treatment : is a group III steroid without antibiotics sufficent therapy? Experimental and clinical studies

    Författare :Per Emgård; Sten Hellström; Dan Bagger-sjöbäck; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; external otitis; external auditory canal EAC ; animal model; treatment; betamethasone; hydrocortisone; antibiotics; human study; Pseudomonas aeruginosa; Candida albicans.; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Oto-Rhino-Laryngology; oto-rhino-laryngologi;

    Sammanfattning : ABSTRACT External otitis and its treatment. Is a group III steroid without antibiotics sufficient therapy? – Experimental and clinical studies Per Emgård, Department of Otorhinolaryngology, University of Umeå and Ystad Hospital, Umeå and Ystad, Sweden External otitis is one of the most common ear, nose and throat (ENT) diagnoses in out-patient clinics. LÄS MER

  7. 10. Characterization of the in vivo mechanisms of action of cell envelope-targeting antibiotics

    Författare :Ann-Britt Schäfer; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mode of action; antimicrobial peptides; cell-envelope targeting; antibiotics;

    Sammanfattning : Multidrug-resistant bacteria pose a major threat to society. Once easily treatable diseases are now challenging to cure. With the golden age of antibiotics being over, the discovery of new antibiotics has been stagnant, and no new antibiotic class has been introduced into the clinic since 2003. LÄS MER