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  1. 1. Unpacking Rational Use of Antibiotics : Policy in Medical Practice and the Medical Debate

    Författare :Hedvig Gröndal; Tora Holmberg; Ericka Johnson; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Antibiotics; Policy; Medical Sociology; Actor-Network Theory; Human-microbial relations; Antimicrobial Resistance; Everyday Infections; Material semiotics; Medical sociology; Medical objects; Medical technologies; Medical knowledge; Sociologi; Sociology;

    Sammanfattning : Rational use of antibiotics–using antibiotics only when needed and in the right way–is a prioritized goal in policy aimed at preventing antimicrobial resistance. A vast body of research is devoted to understanding why unnecessary antibiotics are prescribed. LÄS MER

  3. 2. A tale of two antibiotics : Fusidic acid and Viomycin

    Författare :Mikael Holm; Suparna Sanyal; Scott Blanchard; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Synthesis; Antibiotics; Fusidic acid; Viomycin; Translocation; Accuracy; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Antibiotics that target the bacterial ribosome make up about half of all clinically used antibiotics. We have studied two ribosome targeting drugs: Fusidic acid and Viomycin. Fusidic acid inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) on the ribosome, thereby inhibiting translocation of the bacterial ribosome. LÄS MER

  4. 3. Resistant pneumococci and use of antibiotics

    Författare :Eva Melander; Malmö Klinisk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; Mikrobiologi; mycology; virology; streptococcus pneumoniae; Antibiotics; drug resistance; bacteriology; Microbiology; virologi; mykologi;

    Sammanfattning : Pneumococcal resistance to antibiotics has become a worldwide problem. The rapid increase in frequency seems to be caused by intercontinental spread of a few resistant clones. Resistance to antibiotics in pneumococci has reduced the therapeutic arsenal for common respiratory tract infections as well as for invasive infections. LÄS MER

  5. 4. Antibiotics and infusion phlebitis. Clinical and experimental studies

    Författare :Peter Lanbeck; Enheten för infektionssjukdomar; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infections; HUVEC; endothelium vascular; Infektioner; ICAM-1; 3H-thymidine incorporation; cloxacillin; dicloxacillin; phlebitis epidemiology; Antibiotics; phlebitis chemically induced;

    Sammanfattning : Intravenous administration of antibiotics is often followed by infusion phlebitis. In this condition are vessel irritation, inflammation and sometimes superficial thrombosis included. In this thesis, the risk for infusion phlebitis for various antibiotics has been evaluated in a clinical study in 550 patients. LÄS MER

  7. 5. Molecular Interplay of Antibiotics on the Bacterial Ribosome

    Författare :Narayan Prasad Parajuli; Suparna Sanyal; Michael Y. Pavlov; Chandra Sekhar Mandava; Axel Innis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Translation; Antibiotics; Aminoglycoside; Thermorubin; Protein synthesis; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Inhibition of protein synthesis is one of the most common modes of action for medically useful antibiotics. This thesis presents the mechanistic studies of two chemically distinct classes of antibiotics that target bacterial ribosomes –aminoglycosides and thermorubin. LÄS MER