Sökning: "Antibiotic synergy"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Antibiotic synergy.

1. 1. Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae : Treatment, Selection and International Spread

   Författare :Thomas Tängdén; Otto Cars; Anders Johansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; Klebsiella pneumoniae; extended-spectrum beta-lactamases; carbapenemases; metallo-beta-lactamases; synergy; antibiotic interventions;

   Sammanfattning : The prevalence of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases is increasing worldwide. Therapeutic options for infections with these bacteria are limited not only by the production of ESBLs and carbapenemases, which confer resistance to cephalosporins and carbapenems, but also by frequent co-resistance to other antibiotics. LÄS MER

3. 2. Interactions between β-haemolytic streptococci and the human host. Heart, skin and beyond

   Författare :Anna Bläckberg; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-haemolytic streptococci; Streptococcus dysgalactiae; Streptococcus pyogenes; Erysipelas; Infective endocarditis; Antibiotic synergy; Bacteraemia; Time to positivity;

   Sammanfattning : Group C and G streptococci (GCS/GGS) and group A streptococci (GAS) belong to β-haemolytic streptococci (BHS). GCS/GGS can further be species determined to S. dysgalactiae, whereas S. pyogenes are GAS. LÄS MER

4. 3. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

   Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER

5. 4. Antibiotic interactions and selection for resistance in biofilms

   Författare :Po-Cheng Tang; Dan I. Andersson; Karin Hjort; Mark Webber; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotics; Mikrobiologi; Microbiology;

   Sammanfattning : The challenges posed by antibiotic-resistant bacteria in treating infections, particularly those associated with biofilms, require a deeper understanding of this lifestyle and its connection to resistance selection. Additionally, gaining insights into drug interactions is crucial for enhancing combination treatment efficacy and mitigating resistance development. LÄS MER

7. 5. Genotypic and phenotypic characterisation of Staphylococcus epidermidis isolated from prosthetic joint infections

   Författare :Bengt Hellmark; Bo Söderquist; Magnus Unemo; Åsa Nilsdotter; Tor Monsén; Örebro universitet; []
   Nyckelord :Staphylococcus epidermidis; prosthetic joint infections; antibiotic susceptibility; virulence factors; epidemiology; MLST; agr; SCCmec; MEDICINE; MEDICIN; Biomedicin; Biomedicine;

   Sammanfattning : Staphylococcus epidermidis has emerged in recent years as an important nosocomial pathogen, especially in infections associated with implanted foreign body materials (e.g., prosthetic joints and heart valves) and in individuals with a compromised immune system (e.g. LÄS MER