Sökning: "Anthony Wright"

Visar resultat 6 - 10 av 11 avhandlingar innehållade orden Anthony Wright.

1. 6. Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe

   Författare :Anna Johnsson; Anthony Wright; Mattias Mannervik; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The organisation of eukaryotic DNA into chromatin provides a natural barrier that prevents full access to the DNA thereby inhibiting events such as transcription, replication and repair. In order for these DNA-related events to occur, the chromatin needs to be modified by chromatin remodelling or, by reversible post-translational modifications. LÄS MER

3. 7. Epigenetic gene regulation in multiple myeloma and mood disorders

   Författare :Antonia Kalushkova; Fredrik Öberg; Helena Jernberg-Wiklund; Lucia Cavelier; Anthony Wright; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IKKα; retinoic acid receptor; multiple myeloma; Polycomb; Ouabain; mood disorders;

   Sammanfattning : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. LÄS MER

4. 8. Genome-wide Studies of Transcriptional Regulation in Yeast

   Författare :Jakub Orzechowski Westholm; Jan Komorowski; Anthony Wright; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Bioinformatik;

   Sammanfattning : In this thesis, nutrient signalling in yeast is used as a model to study several features of gene regulation, such as combinatorial gene regulation, the role of motif context and chromatin modifications. The nutrient signalling system in yeast consists of several pathways that transmit signals about the availability of key nutrients, and regulate the transcription of a large part of the genome. LÄS MER

5. 9. Role of c-Myc in the regulation of rDNA transcription by RNA polymerase I

   Författare :Chiou-Nan Shiue; Anthony Wright; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Ribosomal biogenesis and protein translation are finely coordinated with cell proliferation. All three RNA polymerases Pol I, II, and III are utilized for highly efficient and accurate ribosome production. The transcriptional activity of Pol I has been found to be a key determinant for ribosome biogenesis. LÄS MER

7. 10. Histone deacetylases and their co-regulators in schizosaccharomyces pombe

   Författare :Rebecka A. Silverstein; Karl Ekwall; Anthony Wright; Fred Van Leeuwen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The DNA in every eukaryotic cell is wrapped around eight core histones to form the nucleosome. Therefore all events that involve DNA must also involve chromatin and nucleosomes. By regulating chromatin structure the cell can regulate the reactivity of the DNA. LÄS MER