Sökning: "Animal models in research"

Visar resultat 11 - 15 av 211 avhandlingar innehållade orden Animal models in research.

  1. 11. Norovirus and rotavirus susceptibility : studies from a Nicaraguan birth cohort

    Författare :Yaoska Reyes; Johan Nordgren; Lennart Svensson; Miren Iturriza-Gómara; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Norovirus; Rotavirus; Birth cohort; Gastroenteritis; Incidence; Children; Secretor; Immune response.;

    Sammanfattning : Norovirus and rotavirus are major causes of pediatric acute gastroenteritis (AGE). It is estimated that norovirus is responsible for ~20% of all diarrheal diseases in children worldwide and causes approximately 200,000 deaths each year, mostly in young children and the elderly. LÄS MER

  3. 12. Challenges in experimental stroke research : The 17β-estradiol example

    Författare :Edvin Ingberg; Jakob Ström; Elvar Theodorsson; Annette Theodorsson; Tomas Deierborg; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Ischemic stroke causes millions of deaths around the world each year, and surviving patients often suffer from long-term disability. Hundreds of promising drug candidates have been identified in animal models, but the clinical trials have repeatedly failed. Lack of methodological quality in the animal studies, e.g. LÄS MER

  4. 13. Models and biomarkers of motor and neuropsychiatric complications in Parkinson’s disease

    Författare :Katrine Skovgård; Basala gangliernas patofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease Parkinsonism; Dyskinesia; Drug-Induced; Oscillations; Local field potentials; Impulsive-compulsive behaviours; Dopamine agonists; Animal Models; Pharmacology;

    Sammanfattning : Parkinson's disease (PD) is a neurodegenerative disorder characterised by typicalmotor symptoms that are caused by severe dopamine depletion in the cortico-basalganglia network. Parkinsonian motor symptoms are improved by dopaminergicmedications, the most effective being the dopamine precursor L-DOPA. LÄS MER

  5. 14. Behavioral effects of female sex steroid hormones : models of PMS and PMDD in Wistar rats

    Författare :Magnus Löfgren; Torbjörn Bäckström; Inga-Maj Johansson; Per Södersten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; PMS; PMDD; rats; progesterone; estradiol; behavior; individual response; stress interaction; tolerance; withdrawal; learning and memory; anxiety.; Biological research on drug dependence; Biologisk beroendeforskning; Endocrinology; Endokrinologi; Obstetrics and gynaecology; Obstetrik och gynekologi; Pharmacological research; Farmakologisk forskning; Obstetrics and gynaecology; Obstetrik och gynekologi; Psychology; Psykologi; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Background Animal models can be used to mimic human conditions of psychopathology, and also as pre-clinical models to evaluate candidate drugs. With hormonal treatment it is possible to produce behavior in the rat which corresponds to the mental symptoms of pre-menstrual syndrome (PMS), and pre-menstrual dysphoric disorder (PMDD). LÄS MER

  7. 15. Refinement of porcine models in diabetes and transplantation research

    Författare :Elin Manell; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Animal models are widely used in biomedical research aiming to prevent and improve treatments of diseases. The 3Rs (replace, reduce, refine) are considered when working with laboratory animals. Socialisation and training of pigs in research are important to avoid stress responses that could potentially affect research data. LÄS MER