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1. 1. Methodological aspects on microdialysis sampling and measurements

   Författare :Pernilla Abrahamsson; Ola Winsö; Michael Haney; Anna-Maja Åberg; Urban Ungerstedt; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microdialysis; liver ischemia; heart ischemia; epicardium; liver parenchyma; CMA 600; metabolism; Anaesthetics and intensive care; Anestesiologi och intensivvård; anestesiologi; Anaesthesiology;

   Sammanfattning : Background:     The microdialysis (MD) technique is widely spread and used both experi­mentally and in clinical practice. The MD technique allows continuous collection of small molecules such as glucose, lactate, pyruvate and glycerol. Samples are often analysed using the CMA 600 analyser, an enzymatic and colorimetric analyser. LÄS MER

3. 2. Experimental cardiopulmonary cerebral resuscitation : with special reference to cerebral eicosanoid production and free radical scavengers

   Författare :Xiaoli Liu; Marianne Forsman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; cerebral resuscitation; reperfusion damage; oxidative injury; eicosanoid; free radical scavenger; neurological function; alkaline buffer; S-PBN; PBN; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård; Anestesiologi; Anaesthesiology;

   Sammanfattning : Reperfusion injury after restoration of spontaneous circulation (ROSC) is often considered one of the predominant factors in determining neurological outcome in cardiac arrest. Therefore one of the main targets of experimental and clinical studies has been to mitigate this reperfusion injury. LÄS MER

4. 3. Cerebral Protection in Experimental Cardiopulmonary Resuscitation : With Special Reference to the Effects of Methylene Blue

   Författare :Adriana Miclescu; Lars Wiklund; Samar Basu; Jo Kramer-Johansen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac arrest; cardiopulmonary resuscitation; reperfusion injury; methylene blue; nitric oxide; nitric oxide synthases; blood-brain barrier; Anaesthetics and intensive care; Anestesiologi och intensivvård; Anestesiologi; Anaesthesiology;

   Sammanfattning : Although survival rates are increasing, brain injury continues to be a leading cause of death after cardiac arrest (CA). Permanent brain damage after CA is determined by limited tolerance to ischemia from CA and cardiopulmonary resuscitation (CPR), as well as the unique cerebral response to reperfusion after return of spontaneous circulation (ROSC). LÄS MER

5. 4. Transesophageal Echocardiography in Patients Undergoing Elective Coronary Artery Bypass Surgery

   Författare :Ingrid Palmgren; Russell Anderson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology and intensive care; transesophageal echocardiography; low-dose dobutamine; viability; coronary artery bypass; Anestesiologi och intensivvård; Anaesthetics and intensive care; Anestesiologi och intensivvård; anestesiologi; Anaesthesiology;

   Sammanfattning : Transesophageal echocardiography (TEE) has become a useful tool in monitoring the heart in patients during open-heart surgery. This study was undertaken to evaluate whether it is feasible to use TEE to assess left ventricular myocardial viability in anesthetized patients scheduled for coronary artery bypass grafting (CABG). LÄS MER

7. 5. Severe cerebral emergency : aspects of treatment and outcome in the intensive care patient

   Författare :Marie Rodling Wahlström; Silvana Naredi; Sven-Erik Gisvold; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; severe traumatic brain injury; intracranial pressure-targeted therapy; albumin; prostacyclin; endothelial dysfunction; pro-inflammatory cytokines; subarachnoid haemorrhage; asymmetric dimethylarginine; Anaesthetics and intensive care; Anestesiologi och intensivvård; Anaesthesiology; anestesiologi;

   Sammanfattning : Severe Traumatic Brain Injury (TBI) and aneurysmal Subarachnoid Hemorrhage (SAH) are severe cerebral emergencies. They are common reasons for extensive morbidity and mortality in young people and adults in the western world. LÄS MER