Sökning: "Andreas Hober"

Hittade 2 avhandlingar innehållade orden Andreas Hober.

1. 1. Development of novel affinity enrichment strategies for clinical applications using selected reaction monitoring

   Författare :Andreas Hober; Mathias Uhlén; Fredrik Edfors; Björn Forsström; Johan Malmström; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; proteomics; mass spectrometry; selected reaction monitoring; absolute quantification; antibody validation; precision medicine; Biotechnology; Bioteknologi;

   Sammanfattning : Proteins are key components of any living organism and an essential part of life itself. They can provide cells with structure and perform life-sustaining intracellular reactions. As organisms grow more complex, this task expands even further. LÄS MER

3. 2. Bifunctional ADAPTs: Opportunity for serological Half-life extension and Targeted therapy

   Författare :Andreas Wisniewski; Sophia Hober; Masood Kamali-Moghaddam; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Autoimmune diseases; Cancer; Half-life extension; HRP; Phage Display; Protein Engineering; Targeted therapy; Biotechnology; Bioteknologi;

   Sammanfattning : Small engineered scaffold proteins (ESPs) gain more and more popularity as biological drugs, due to their specificity and applicability in diagnostics and therapy. Thanks to their high stability, low immunogenicity and low production cost, they present themselves as a promising alternative to the market-leading antibodies. LÄS MER