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Visar resultat 1 - 5 av 10 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Cellular Reactions and Behavioral Changes in Focal and Diffuse Traumatic Brain Injury : A Study in the Rat and Mouse

   Författare :Sara Ekmark Lewén; Lars Hillered; Niklas Marklund; Anders Lewén; Mårten Risling; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Astrocytes; Inflammatory response; Multivariate concentric square field test; Morris water maze; Exploratory behavior; Risk taking; Functional outcome.; Neurosurgery; Neurokirurgi;

   Sammanfattning : Traumatic brain injury (TBI) is a severe condition and a major cause of death and disability. There is no pharmacological treatment available in clinical practice today and knowledge of brain injury mechanisms is of importance for development of neuroprotective drugs. LÄS MER

3. 2. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

   Författare :Anders Lewén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

   Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

4. 3. Clinical Bedside Studies of Cerebral Blood Flow in Severe Subarachnoid Hemorrhage Using Xenon CT

   Författare :Henrik Engquist; Per Enblad; Elham Rostami; Anders Lewén; Marianne Juhler; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Subarachnoid hemorrhage; delayed cerebral ischemia; cerebral blood flow; HHH-therapy; triple-H; xenon CT; XeCT; cerebral microdialysis; Neurokirurgi; Neurosurgery;

   Sammanfattning : Aneurysmal subarachnoid hemorrhage (SAH) is frequently complicated by delayed cerebral ischemia (DCI), contributing to poor outcome. Particularly for patients in poor neurological state, prediction of the acute clinical course is difficult, as is the early detection of DCI. LÄS MER

5. 4. Molecular Characterization of Experimental Traumatic Brain Injury

   Författare :Charlotte Israelsson; Ted Ebendal; Lars Hillered; Anders Lewén; Henrik Hagberg; Uppsala universitet; []
   Nyckelord :Neurosciences; traumatic brain injury; transcripts; GeneChip; chemokine; inflammation; mouse brain; neuroprotection; neuronal injury; neuroregeneration; astrocytosis; Neurovetenskap;

   Sammanfattning : Traumatic brain injury (TBI) is the most common cause of mortality and disability in the younger (.... LÄS MER

7. 5. Traumatic brain injury in elderly patients

   Författare :Samuel Lenell; Per Enblad; Anders Lewén; Alfonso Lagares; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Traumatic brain injury; Elderly; Outcome; Standardized neurosurgical intensive care; Quality register; Prognostic factors; Secondary insults; Neurointensive care monitoring; Pressure reactivity index; Optimal cerebral perfusion pressure; Cerebral autoregulation; Neurokirurgi; Neurosurgery;

   Sammanfattning : The increase of elderly traumatic brain injury (TBI) patients constitutes a considerable challenge. The aim was therefore to specifically study elderly TBI patients with respect to patient characteristics, neurointensive care (NIC) and outcome, and to identify age specific features, which may be important for selection of patients and optimization of NIC in the elderly. LÄS MER