Sökning: "Anders Karlsson uppsala"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Anders Karlsson uppsala.

  1. 1. Combinatorial and analytical problems for fractals and their graph approximations

    Författare :Konstantinos Tsougkas; Anders Karlsson; Anders Öberg; Ben Hambly; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fractal graphs; energy Laplacian; Kusuoka measure; Mathematics; Matematik;

    Sammanfattning : The recent field of analysis on fractals has been studied under a probabilistic and analytic point of view. In this present work, we will focus on the analytic part developed by Kigami. The fractals we will be studying are finitely ramified self-similar sets, with emphasis on the post-critically finite ones. LÄS MER

  3. 2. Benefits of Pharmacometric Model-Based Design and Analysis of Clinical Trials

    Författare :Kristin E Karlsson; E Niclas Jonsson; Mats O Karlsson; Anders Grahnén; Michael K Smith; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; model-based analysis; pharmacometrics; modeling; disease progression; NONMEM; SAEM; Importance sampling; repeated time-to-event; RTTCE; RCEpT; NIH stroke scale; Barthel index; internal validation; external validation; study power; study design; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Sammanfattning : Quantitative pharmacokinetic-pharmacodynamic and disease progression models are the core of the science of pharmacometrics which has been identified as one of the strategies that can make drug development more effective. To adequately develop and utilize these models one needs to carefully consider the nature of the data, choice of appropriate estimation methods, model evaluation strategies, and, most importantly, the intended use of the model. LÄS MER

  4. 3. The effect of mechanical ventilation on abdominal organs : Analysing the role of PEEP and perfusion

    Författare :Silvia Marchesi; Miklós Lipcsey; Anders Larsson; Göran Hedenstierna; Torbjörn Karlsson; Anders Oldner; Ragnvi Hagman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ARDS; sepsis; abdominal inflammation; edema; perfusion; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Background: The effect of mechanical ventilation on abdominal organs is not well understood and investigated yet. Previous studies, using an animal sepsis-like model, found an association between mechanical ventilation (MV) and abdominal edema and inflammation. LÄS MER

  5. 4. Evaluation of a Miniaturized Rotating Disk Apparatus for In Vitro Dissolution Rate Measurements in Aqueous Media : Correlation of In Vitro Dissolution Rate with Apparent Solubility

    Författare :Anita M. Persson; Curt Pettersson; Anders Sokolowski; Anders Karlsson; Alex Avdeef; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; analytical methods; HPLC high-performance liquid chromatography ; miniaturization; in vitro dissolution rate; apparent solubility; physicochemical properties; dissolution media; correlation study; chemometrics; Pharmaceutical chemistry; Farmaceutisk kemi; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : The general aim of this thesis was to evaluate a newly designed and constructed miniaturized rotating disk apparatus for in vitro dissolution rate measurements of different drug substances from all of the classes in the Biopharmaceutical Classification System (BCS). The new equipment is based on a low volume flow-through cell of Plexiglas, a gold plated magnetic bar and a special designed press. LÄS MER

  7. 5. Direct separation of enantiomers using chiral ion-pair chromatography

    Författare :Anders Karlsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER