Sökning: "Anastasia Simi"

Hittade 1 avhandling innehållade orden Anastasia Simi.

1. 1. Molecular basis for the anti-inflammatory properties of chlomethiazole

   Författare :Anastasia Simi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Stroke; neuroprotection; p38 MAP kinase; chlomethiazole; interleukin-1; c-fos; inflammation; glia; lipopolysaccharide; molecular mechanisms; ischaemia;

   Sammanfattning : Chlomethiazole (CMZ) exerts neuroprotective effects in animal models of stroke, and its clinical efficacy is currently evaluated in acute stroke patients. CMZ also protects the liver from alcohol- induced oxidative damage by inhibiting the cytochrome P450 2E1 (CYP2E1), as well as inflammation associated with alcohol liver disease (ALD) by inhibiting cytokine expression. LÄS MER