Sökning: "Analytical gradients"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden Analytical gradients.

  1. 1. Advances in analytical methodologies for studies of the platinum metallome in malignant cells exposed to cisplatin

    Författare :Yvonne Nygren; Erik Björn; Knut Irgum; Bente Gammelgaard; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Method development; Metallome; Inductively coupled plasma mass spectrometry; Electrospray ionization mass spectrometry; Liquid chromatography; Hyphenation; Organic modifier; Cisplatin; Platinum; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Sammanfattning : The scientific progress about the important chemotherapeutic drug substance cisplatin (CDDP) and its function has often been rendered by data difficult to interpret, and still many questions about its mode of action remains to be clarified by the scientific community. However, studies of CDDP possess a high complexity due to; i) low intracellular concentration, ii) many potential biomolecule targets, iii) poor or unknown stability of the intact drug and its biomolecule adducts and iv) complex and varying sample matrices. LÄS MER

  3. 2. Flow injection systems for process analytical chemistry

    Författare :Ingrid Lukkari; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Flow injection; Sequential injection; Process analytical chemistry; Multivariate calibration; Sensor injection; Gas-diffusion; Sample clean-up;

    Sammanfattning : Flow injection systems have great potential for sample handling and analysis in process analytical chemistry. The flexibility and versatility of flow injection manifolds can he utilized in specific applications of sample conditioning and analysis. LÄS MER

  4. 3. Solving Analytical Challenges with Thin Layer Electrochemistry

    Författare :Alexander Wiorek; Gaston A. Crespo; Maria Cuartero; Gregoire Herzog; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Thin Layer Electrochemistry; Polyaniline; Carbon nanotubes; Ion-selective electrodes; Ionophores; Electrochemical Sensors; Alkalinity; Deionization; Chemical Imaging; Tunnskiktselektrokemi; polyanilin; kolnanorör; jonselektiva elektroder; jonoforer; elektrokemiska sensorer; Alkalinitet; avjonisering; chemical imaging; Kemi; Chemistry;

    Sammanfattning : The decentralization of chemical sensing to attain environmental-related information is today highly desirable to increase the knowledge on biological or geological events as well as effluents. The current state of the field moves toward submersible probes; chemical sensors implemented into submersible devices for quantifying analytes over extended times. LÄS MER

  5. 4. Fundamental and Regulatory Aspects of UHPLC in Pharmaceutical Analysis

    Författare :Dennis Åsberg; Torgny Fornstedt; Jörgen Samuelsson; Gert Desmet; Karlstads universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Liquid chromatography; UHPLC; Pharmaceutical analysis; Adsorption isotherm; Design of experiments; Quality control; Kemi; Chemistry;

    Sammanfattning : Ultra-high performance liquid chromatography (UHPLC) provides a considerable increase in throughput compared to HPLC and a reduced solvent consumption. The implementation of UHPLC in pharmaceutical analysis, e.g. LÄS MER

  7. 5. Techniques to manipulate the environment around and inside single cells

    Författare :Helen Bridle; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; digitonin; solution exchange; microfluidics; oscillations; temperature control; ion channels; valves;

    Sammanfattning : Several methods for extending the functionality of a commercially available microfluidic system have been developed to allow for the manipulation of the extracellular and intracellular environments. The microfluidic system generates a chemically patterned laminar flow in an open volume. LÄS MER