Sökning: "Ana Martin-Villalba"

Hittade 2 avhandlingar innehållade orden Ana Martin-Villalba.

1. 1. Molecular and Cellular Complexity of Glioma : Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

   Författare :Demet Çağlayan; Bengt Westermark; Maria Ferletta; Ana Martin-Villalba; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

   Sammanfattning : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. LÄS MER

3. 2. Glioblastoma heterogeneity and plasticity : Investigating the roles of BMP4 and SOX2

   Författare :Erika Dalmo; Bengt Westermark; Fredrik J. Swartling; Lene Uhrbom; Ana Martin-Villalba; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; SOX2; BMP4; senescence; plasticity; Oncology; Onkologi; Medicinsk vetenskap; Medical Science; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

   Sammanfattning : The malignant primary brain tumor glioblastoma has a dismal prognosis and is distinguished by its heterogeneous character. Current treatment with surgical resection, radiotherapy and adjuvant chemotherapy with the alkylating agent temozolomide does not provide a cure, but simply prolongs survival by a few months. LÄS MER