Sökning: "Amyotrofisk lateralskleros"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Amyotrofisk lateralskleros.
1. Superoxide dismutase 1 and amyotrophic lateral sclerosis
Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the spinal cord, brain stem and motor cortex, leading to paralysis, respiratory failure and death. In about 5% of ALS cases, the disease is associated with mutations in the CuZn-superoxide dismutase (hSOD1) gene. LÄS MER
2. Misfolded superoxide dismutase-1 in sporadic and familial Amyotrophic Lateral Sclerosis
Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative syndrome of unknown etiology that most commonly affects people in middle and high age. The hallmark of ALS is a progressive and simultaneous loss of upper and lower motor neurons in the central nervous system that leads to a progressive muscle atrophy, paralysis and death usually by respiratory failure. LÄS MER
3. The novel sources of the neurotoxin BMAA in aquatic environments
Sammanfattning : Neurotoxinet β -N-metylamino -L-alanin (BMAA) anses vara en potentiell miljöriskfaktor för utvecklingen av den neurodegenerativa sjukdomen amyotrofisk lateralskleros (ALS) och har en potentiell roll i flertalet andra neurodegenerativa sjukdomar. Sedan 2003, då det upptäcktes att BMAA produceras av den symbiotiska cyanobakterien Nostoc punctiforme har flera andra BMAA producerande cyanobakteriearter identifierats. LÄS MER
4. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS
Sammanfattning : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. LÄS MER
5. Extraocular Muscles in Amyotrophic Lateral Sclerosis
Sammanfattning : Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease of motor neurons characterized by muscle paralysis and death within 3-5 years of onset. However, due to unknown mechanisms, the extraocular muscles (EOMs) remain remarkably unaffected. LÄS MER