Sökning: "Amyloid beta 1-40"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Amyloid beta 1-40.

  1. 1. The Impact of Amyloid Peptides on Pericytes in Alzheimer's Disease

    Författare :Nina Schultz; Klinisk minnesforskning; []
    Nyckelord :Pericytes; Alzheimer s disease; Amyloid peptides; IAPP; Amyloid beta 1-42; Amyloid beta 1-40; Cell death; NG2; Retina; Hippocampus;

    Sammanfattning : .... LÄS MER

  3. 2. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

    Författare :Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. LÄS MER

  4. 3. Developing a Porcine Model to Study the Glymphatic System

    Författare :Nicholas Bechet; Glia-Immune Interactions; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glymphatic system; cerebrospinal fluid; Porcine; in vivo imaging; amyloid beta; Alzheimer disease;

    Sammanfattning : The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through the brain. LÄS MER

  5. 4. Molecular mechanisms in amyloid fibril formation

    Författare :Waltteri Hosia; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis concerns investigations on molecular processes and interactions that lead to amyloid fibril formation. Pulmonary surfactant protein C (SP-C), and a synthetic analogue thereof, SP-C(Leu), have similar properties in terms of charge distribution, hydrophobicity and secondary structure, yet they differ in their aggregation propensities. LÄS MER

  7. 5. Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice

    Författare :Amelia Marutle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ageing; Alzheimer s disease; P-amyloid; Nicotinic acetylcholine receptor subtypes; Postmortem human brain; Schizophrenia; Transgenic mice;

    Sammanfattning : Neuronal nicotinic acetylcholine receptors (nAChRs) are transmitter-gated ion channel receptors which are widely distributed in the brain. They mediate the effects of several neurotransmitters including ACh, DA, 5-HT and NA and are important for many normal physiological functions in the brain and are also implicated in a number of CNS disorders, such as AD, PD, schizophrenia, Tourette's syndrome and familial epilepsy. LÄS MER