Sökning: "Amyloid Beta"

Visar resultat 11 - 15 av 170 avhandlingar innehållade orden Amyloid Beta.

  1. 11. Revealing the complex nature of amyloid beta and its relation to dementia

    Författare :Eleni Gkanatsiou; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s Disease; Amyloid beta; Mass spectrometry; Cerebral amyloid angiopathy; Down Syndrome; Pathological ageing; Dementia with Lewy bodies; Parkinson s disease dementia; dementia;

    Sammanfattning : Alzheimer disease (AD) is the most common type of dementia and characterized by the accumulation of amyloid plaques in the extracellular space of the brain parenchyma. Amyloid plaques consist of amyloid beta peptides (Aβ). Amyloid pathology can also be involved in other types of dementia, either as a driving force or as a coexisting pathology. LÄS MER

  3. 12. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Författare :Kina Höglund; Göteborgs universitet; []
    Nyckelord :Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Sammanfattning : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. LÄS MER

  4. 13. NMR studies of the amyloid beta-peptide

    Författare :Jens Danielsson; Astrid Gräslund; Chris Dobson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; Biophysics; Biofysik;

    Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER

  5. 14. Structure and dynamics of amyloid-beta oligomers

    Författare :Faraz Vosough; Andreas Barth; Henrietta Nielsen; Oxana Klementieva; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta peptide; Aβ oligomer; infrared spectroscopy; FTIR; protein aggregation; β-sheet; interaction; lithium; nickel; biokemi; Biochemistry;

    Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia, affects tens of millions of people all over the world and inflicts huge socioeconomic costs on the societies. AD is a neurodegenerative disease; it progresses over time and is highly debilitating at the advanced stages. LÄS MER

  7. 15. The Impact of Amyloid Peptides on Pericytes in Alzheimer's Disease

    Författare :Nina Schultz; Klinisk minnesforskning; []
    Nyckelord :Pericytes; Alzheimer s disease; Amyloid peptides; IAPP; Amyloid beta 1-42; Amyloid beta 1-40; Cell death; NG2; Retina; Hippocampus;

    Sammanfattning : .... LÄS MER