Sökning: "Alzheimer s disease"

Visar resultat 26 - 30 av 79 avhandlingar innehållade orden Alzheimer s disease.

  1. 26. Molecular changes of acetylcholinesterase and butyrylcholinesterase in Alzheimer patients during the natural couse of the disease and treatment with cholinesterase inhibitors : insight into neurochemical mechanisms affecting the progression of the disease

    Författare :Taher Darreh-Shori; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer disease; acetylcholinesterase; butyrylcholinesterase; cholinesterase inhibitors;

    Sammanfattning : Deficits in central cholinergic neurotransmission in the brain correlate with cognitive impairment in Alzheimer disease (AD) patients. This fact has resulted in the introduction of cholinesterase inhibitors (ChEls) e.g. LÄS MER

  3. 27. Increasing the interpretability of Alzheimer-related biomarkers: cell- and cerebrospinal fluid-based studies with focus on neurogranin

    Författare :Faisal Hayat Nazir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; biomarker; neurogranin; APP; human iPSCs; CSF;

    Sammanfattning : Biomarkers for Alzheimer’s disease (AD) is a growing field of research. A particularly vibrant field during recent years has been biomarkers for synaptic dysfunction. LÄS MER

  4. 28. Search for reliable diagnostic markers for Alzheimer’s disease

    Författare :Niels Andreasen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer´s disease; Mild cognitive impairment; Biochemical markers; Cerebrospinal fluid; Diagnosis; Progression; Tau-protein; Beta-amyloid; Aß42; ApoE; Sensitivity; Specificity;

    Sammanfattning : The diagnosis of Alzheimer’s disease (AD) is rather difficult not at least in the earlier stages of the disease. The diagnostic accuracy has been reported to be around 65-90%. These figures however, come from academic centers with a special interest in the disease and are based on patients followed for several years. LÄS MER

  5. 29. Cardiac and vascular pathology in Lewy body disease and Alzheimer's disease: exploring neurocognitive disorder beyond the brain

    Författare :Keivan Javanshiri; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The first aim of this thesis was to evaluate the prevalence of cardiovascular disease (CaVD), hypertension (HT), and type 2 diabetes mellitus (T2DM) in the neurodegenerative disorders Alzheimer’s disease (AD) and Lewy body disease (LBD). These conditions are considered modifiable risk factors for vascular dementia (VaD), and recent research has proposed its association with AD. LÄS MER

  7. 30. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease

    Författare :Zhi Tang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. LÄS MER