Sökning: "Alzheimer s disease"

Visar resultat 16 - 20 av 79 avhandlingar innehållade orden Alzheimer s disease.

  1. 16. Proteomic strategies for analysis of cerebrospinal fluid in neurodegenerative disorders

    Författare :Sara Folkesson Hansson; Göteborgs universitet; []
    Nyckelord :Alzheimer?s disease; frontotemporal dementia; cerebrospinal fluid; neurodegeneration; proteomics; mass spectrometry; prefractionation; protein identification; quantification;

    Sammanfattning : ABSTRACT There is a great need for biomarkers to diagnose neurodegenerative disorders, such as the cognitive disorders Alzheimer?s disease (AD) and frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) is in contact with the extracellular fluid of the brain and is consequently a valuable medium for identifying biomarkers for neurological disorders. LÄS MER

  3. 17. Amyloid β peptide: from monomer solubility to fibril structure

    Författare :Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Sammanfattning : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. LÄS MER

  4. 18. Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : animal and cellular models

    Författare :Ewa Kloskowska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The amyloid precursor protein (APP) and it s derivatives play a key role in the pathogenesis of Alzheimer s disease (AD), which is characterized by the presence of multiple aggregates of an APP proteolytic product, Ab, and tau protein in the brains of affected patients. Clinically the disease is manifested by a progressive loss of memory and executive functions. LÄS MER

  5. 19. Dementia and other mental disorders among 95-year olds

    Författare :Anne Börjesson-Hanson; Göteborgs universitet; []
    Nyckelord :nonagenarians; 95-year-olds; dementia; Alzheimer?s disease; vascular dementia; depression; anxiety; psychotic; paranoid ideation; cognitive function; mortality; population attributable risk; population study; prevalence; epidemiology; oldest old; very elderly;

    Sammanfattning : The aims of this study were to estimate the prevalence of mental disorders and age related differences in the very elderly. In addition, five-year mortality after age 95 in relation to dementia and cognitive function in non-demented, was examined. LÄS MER

  7. 20. Sleep and cognition in old age: Birth cohort differences, dementia, and biomarkers of Alzheimer´s disease

    Författare :Johan Skoog; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Subjective sleep disturbance; cognition; dementia; epidemiology;

    Sammanfattning : The focus for this thesis is on two major determinants of health and wellbeing in older people, namely subjective sleep disturbance and cognition. Data were drawn from the H70 Birth Cohort Studies, comprising representative samples of older people living in Gothenburg, Sweden. LÄS MER