Sökning: "Alzheimer’s disease"

Visar resultat 16 - 20 av 434 avhandlingar innehållade orden Alzheimer’s disease.

  1. 16. Aβ Conformation Dependent Antibodies and Alzheimer's Disease

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Dag Sehlin; Uppsala universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; protofibrils; conformation; monoclonal antibody; ELISA; MEDICINE; MEDICIN; Geriatrics; Geriatrik;

    Sammanfattning : Soluble intermediates of the amyloid-β (Aβ) aggregation process are suggested to play a central role in the pathogenesis of Alzheimer’s disease (AD) by causing synaptic dysfunction and neuronal loss. In this thesis, soluble Aβ aggregates have been studied with a particular focus on the Aβ protofibril, which has served as the antigen for developing conformation dependent monoclonal antibodies. LÄS MER

  2. 17. Energy metabolism as a target for new treatment strategies in Huntington’s disease

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Marie Sjögren; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington´s disease; Energy metabolic alteration; Weight loss; Skeletal muscle; Adipose tissue; R6 2; Ghrelin; Liraglutide;

    Sammanfattning : Huntington´s disease (HD) is a fatal inherited neurodegenerative disorder caused by a CAG triplet repeat expansion in the huntingtin (HTT) gene and characterized by cognitive and motoric dysfunctions as well as psychiatric problems. Accumulating evidence, however, suggests altered energy metabolism and a hyper-catabolic state as key features of HD pathology. LÄS MER

  3. 18. Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Mattias Haglund; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; pathological anatomy; General pathology; Vascular dementia; Alzheimer s disease; Cerebral infarction; Locus ceruleus; White matter; Microvasculature; Cerebrovascular disease; patologisk anatomi; Ischemia; Cerebral amyloid angiopathy;

    Sammanfattning : Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer's disease and vascular dementia. LÄS MER

  4. 19. Detection of Differentially Expressed Genes in Alzheimer's Disease Regulator of G-protein Signalling 4: A Novel Mediator of APP Processing

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lina Emilsson; Uppsala universitet.; [2005]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; RGS4; ITPKB; RAB3A; APP processinig; NATURAL SCIENCES Biology; NATURVETENSKAP Biologi;

    Sammanfattning : Alzheimer’s disease is a neurodegenerative disease characterised by progressive memory deterioration and cognitive impairment. Pathological hallmarks are extracellular senile plaques, neurofibrillary tangles and neuron loss. Senile plaques are produced through altered processing of the membrane-bound protein APP. LÄS MER

  5. 20. Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Joakim Hertze; Lund University.; Lunds universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; mild cognitive impairment; white matter lesions; brain reserve; blood-brain barrier; angiogenesis; neuroinflammation; neurogranin; YKL-40; VEGF; IGF; ICAM-1; VCAM-1;

    Sammanfattning : Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. LÄS MER