Sökning: "Alzheimer`s peptide Ab"

Visar resultat 6 - 10 av 10 avhandlingar innehållade orden Alzheimer`s peptide Ab.

1. 6. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease

   Författare :Maj-Linda Selenica; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; neurophysiology; Neurology; Medicine human and vertebrates ; Medicin människa och djur ; Clinical chemistry; Klinisk kemi; Kinase inhibitors; Tau protein; Cystatin C; Glycogen Synthase Kinase; Alzheimers Disease; Amyloid beta;

   Sammanfattning : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. LÄS MER

3. 7. Amyloids here, amyloids there…What’s wrong with them?

   Författare :Anna Gharibyan; Ludmilla Morozova-Roche; Tuomas Knowels; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloids; oligomers; fibrils; cytotoxicity; Alzheimer s disease; Aortic stenosis; S100A9; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Amyloid formation is inherent property of proteins which under certain circumstances can become a pathologic feature of a group of diseases called amyloidosis. There are about 30 known human amyloidosis and more than 27 identified proteins involved in these pathologies. LÄS MER

4. 8. Development of molecular recognition by rational and combinatorial engineering

   Författare :Andreas Jonsson; Stefan Ståhl; Mats Persson; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; albumin binding domain; protein engineering; phage display; amyloid beta peptide; TNF; HSA; Molecular biology; Molekylärbiologi;

   Sammanfattning : Combinatorial protein engineering, taking advantage of large libraries of protein variants and powerful selection technology, is a useful strategy for developing affinity proteins for applications in biotechnology and medicine. In this thesis, two small affinity proteins have been subjected to combinatorial protein engineering to improve or redirect the binding. LÄS MER

5. 9. Recombinant BRICHOS domains delivered over the blood-brain barrier : a possible way to treat Alzheimer’s disease

   Författare :Lorena Galán-Acosta; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : One of the current major challenges to treat neurological diseases is the ability of drug candidates to cross the blood-brain barrier (BBB). Alzheimer´s disease (AD) is the most common form of dementia worldwide, affecting more people every year due to a world where the average lifespan is increasing. LÄS MER

7. 10. Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein

   Författare :Anna Bergman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes the most common form of dementia. Pathological lesions, such as plaques consisting of the amyloid beta-peptide (Ab), are found in the brains of AD patients. Ab is produced by sequential cleavages of the amyloid precursor protein (APP) by beta- and gamma-secretase. LÄS MER