Sökning: "Alzheimer`s peptide Ab"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Alzheimer`s peptide Ab.

  1. 1. Alzheimer's Disease: The role of alpha1-antichymotrypsin-amyloid peptide (Abeta 1-42) interaction in the pathogenesis of Alzheimer's disease

    Detta är en avhandling från Yong-Xin Sun, Wallenberg Lab, plan, University Hospital, UMAS, S-205 02, Malmö

    Författare :Yongxin Sun; Lunds universitet.; Lund University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; neurophysiology; Neurologi; neuropsychology; Neurology; lipid metabolism.; inflammation; á1-antichymotrypsin; Alzheimer’s disease; amyloid-â peptide;

    Sammanfattning : Alzheimer?s disease (AD) is an age-related, irreversible brain disorder that occurs gradually and results in memory loss, behavioural and personality changes. The disease is characterized by an abnormal accumulation of amyloid-beta (Ab) peptide in the extracellular space and the protein Tau within nerve cells of certain regions of the brain. LÄS MER

  2. 2. Hydrophobic interactions of serpins

    Detta är en avhandling från Sabina Janciauskiene, Wallenberglab, University Hospital Malmö, S-20502 Malmö, Sweden

    Författare :Sabina Janciauskiene; Lunds universitet.; Lund University.; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteiner; enzymology; polymerization.; Proteins; conformational polymorphism; hydrophobic interaction; amyloid fibrils; Alzheimer`s peptide Ab; alpha-1-antichymotrypsin; C-terminal peptide; lithocholic acid; cholesterol; Key words: alpha-1-antitrypsin; bile acids; enzymologi;

    Sammanfattning : The proteins of the serpin family are primarily but not exclusively proteinase inhibitors, which share a common, similar structure. It is known that this structure undergoes major conformational changes upon cleavage in the serpin reactive site loop, and that these changes include rearrangements within the hydrophobic core of the molecule. LÄS MER

  3. 3. NMR studies of the amyloid beta-peptide

    Detta är en avhandling från Stockholm : Institutionen för biokemi och biofysik

    Författare :Jens Danielsson; Stockholms universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NMR; amyloid beta peptide; structure; metal interaction; diffusion; TECHNOLOGY Engineering physics Biophysics; TEKNIKVETENSKAP Teknisk fysik Biofysik;

    Sammanfattning : The Amyloid beta peptide (Ab) is related to Alzheimer’s disease and is suggested to be the molecular pathogenic species of the disease, probably through the neurotoxic effect of Ab oligomers. Here the results from biophysical studies of Ab and fragments thereof, are presented. LÄS MER

  4. 4. Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Mattias Haglund; Lunds universitet.; Lund University.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; pathological anatomy; General pathology; Vascular dementia; Alzheimer s disease; Cerebral infarction; Locus ceruleus; White matter; Microvasculature; Cerebrovascular disease; patologisk anatomi; Ischemia; Cerebral amyloid angiopathy;

    Sammanfattning : Popular Abstract in Swedish Alzheimers sjukdom och vaskulär demens är de vanligaste orsakerna till demens hos äldre, ett tillstånd som i takt med den ökande åldrade befolkningen kommer att innebära ett allt större lidande och en alltjämt ökande ekonomisk belastning. Direkta och indirekta kostnader för vård och omsorg av demenspatienter uppgår sannolikt till ca 40 miljarder kronor om året. LÄS MER

  5. 5. Biophysical studies on aggregation processes and amyloid fibrils with focus on Alzheimer's disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Clinical Neuroscience

    Författare :Niklas Bark; Karolinska Institutet.; Karolinska Institutet.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fluorescence correlation spectroscopy; amyloid fibril formation; Alzheimer s disease;

    Sammanfattning : Alzheimer's disease (AD) is a fatal neurodegenerative disease, and is the most common form of dementia, affecting 1-2% of the population in industrialized countries. It is believed that intermediate species formed during amyloid Bpeptide (AB) polymerization play a key role in the pathogenesis of AD, but it is not known how such toxic effects are exerted. LÄS MER