Sökning: "Alpha2-adrenergic receptor"

Hittade 3 avhandlingar innehållade orden Alpha2-adrenergic receptor.

  1. 1. Modulation of the Progenitor Cell and Homeostatic Capacities of Müller Glia Cells in Retina : Focus on α2-Adrenergic and Endothelin Receptor Signaling Systems

    Författare :Mohammad Harun-Or-Rashid; Finn Hallböök; Per Ekström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha2-adrenergic receptor; Brimonidine; Brn3a; Dedifferentiation; Endothelin; EGFR; ERK1 2; Neuroprotection; NMDA; MIO-M1 human Müller cell; Müller cells; Retina; Retinal ganglion cells; Src-kinase; Transactivation.; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Müller cells are major glial cells in the retina and have a broad range of functions that are vital for the retinal neurons. During retinal injury gliotic response either leads to Müller cell dedifferentiation and formation of a retinal progenitor or to maintenance of mature Müller cell functions. LÄS MER

  3. 2. Increased glucocorticoid sensitivity in pancreatic beta-cells : effects on glucose metabolism and insulin release

    Författare :Behrous Davani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glucocorticoids; glucocorticoid receptor; Pancreatic beta-cell; Type 2 diabetes; insulin release;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) is characterized by three pathological alterations: (1) insulin resistance in peripheral tissues, (2) increased hepatic glucose production and (3) impaired insulin secretion from the pancreatic beta-cells. Glucocorticoids (GCs) exert profound effects on glucose homeostasis. LÄS MER

  4. 3. Neonatal Exposure to Anaesthesia and Adjuvants : Acute Effects on Cerebral Apoptosis and Neuroproteins, and Late  Behavioural Aberrations in Mice

    Författare :Emma Pontén; Anders Fredriksson; Torsten Gordh; Steen Henneberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anaesthesia; neonatal; apoptosis; bahaviour; clonidine; ketamine; propofol; theophyllamine; Medicin; Medicine;

    Sammanfattning : During a finite developmental phase – the brain growth spurt – the brain grows and matures at an accelerated rate. During this period the brain is more sensitive to harmful substances such as ethanol and environmental toxins than before or after. LÄS MER