Sökning: "Almqvist E"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden Almqvist E.

  1. 1. Synthesis of Ring-fused Peptidomimetics : Interacting with Amyloid Fibrils

    Författare :Dan E. Adolfsson; Fredrik Almqvist; Anna Linusson; Morten Grötli; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; synthesis; peptidomimetics; thiazoline fused 2-pyridones; Alzheimer s disease; Parkinson s disease; Amyloid; Amyloid-beta; alfa-Synuclein; method development; organisk kemi; Organic Chemistry;

    Sammanfattning : Parkinson's and Alzheimer's disease are the two most common neurological disorders in humans. Both conditions involve progressive death of neurons in the central nervous system, decline in bodily functions and eventually (and invariably), death. So far, no cure exists and the available treatments can only ease symptoms. LÄS MER

  3. 2. Constraining the timing of veins, faults and fractures in crystalline rocks by in situ Rb-Sr geochronology

    Författare :Mikael Tillberg; Henrik Drake; Mats E. Åström; Thomas Zack; Johan Hogmalm; Bjarne Almqvist; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; geochronology; brittle deformation; crustal fluids; mineral precipitation; ancient microbial activity; Precambrian craton; Scandinavia; Natural Science; Naturvetenskap;

    Sammanfattning : Precambrian cratons are continent cores archiving the oldest crustal histories on Earth. The crystalline basement of cratons is typically characterized by complex arrays of multiple fracture and fault generations hosting minerals formed by fluids flowing through fracture networks. LÄS MER

  4. 3. Synthesis and functionalization of ring-fused 2-pyridones : Targeting pili formation in E. coli

    Författare :Nils Pemberton; Fredrik Almqvist; Oliver Kappe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; acylketene; antibacterial; biofilm inhibitor; Mannich; Micro-wave-assisted chemistry; peptidomimetic; virulence.; Organic synthesis; Organisk syntes;

    Sammanfattning : Bicyclic dihydrothiazolo fused 2-pyridones have been studied as a new class of antibacterial agents, termed pilicides, that target the formation of adhesive bacterial surface organelles (pili) in pathogenic bacteria. Synthetic methods to further functionalize the bicyclic 2-pyridone scaffold have been developed in order to increase water-solubility and thereby facilitate biological evalua-tions. LÄS MER

  5. 4. Dicarboxylic acids from xylose, using natural and engineered hosts

    Författare :Henrik Almqvist; Avdelningen för kemiteknik; []
    Nyckelord :Xylose; Dicarboxylic Acids; Biorefineries; Actinobacillus succinogenes; Basfia succiniciproducens; Saccharomyces cerevisiae; Caulobacter crescentus;

    Sammanfattning : Chemical building blocks for plastics can be produced from renewable biomass feedstocks using microbial production organisms, such as yeast or bacteria, in a biorefinery. One class of chemical building blocks that are suitable for production of biobased and biodegradable plastics are dicarboxylic acids, e.g. succinic acid. LÄS MER

  7. 5. Epstein-Barr virus nuclear antigen 1, Oct and Groucho/TLE in control of promoter regulation

    Författare :Jenny Almqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EBV; Oct-1; Oct-2; Groucho; TLE; transcription; repression; latency;

    Sammanfattning : The human herpes virus Epstein-Barr virus (EBV) is carried by approximately 95% of the adult population. It can form a lifelong latent infection in the B-cells by avoiding our immune system. A latent EBV infection is usually asymptomatic but a few EBV associated cancer forms has been described (e.g. LÄS MER