Sökning: "Allylic substrates"

Visar resultat 1 - 5 av 31 avhandlingar innehållade orden Allylic substrates.

1. 1. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations

   Författare :Johanna M. Larsson; Kálmán J. Szabó; Dennis G. Hall; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; palladium; copper; catalysis; Heck reaction; C-H functionalization; allylic substitution; silylation; borylation; trifluoromethylation; fluorination; mechanistic study; transition metal; alkene; allylic silane; allylic boronate; allylic fluoride; organisk kemi; Organic Chemistry;

   Sammanfattning : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. LÄS MER

3. 2. Catalytic Methods to Convert Allylic Substrates through Hydride and Proton Shifts : Transition Metal-Catalyzed and Organocatalyzed Approaches

   Författare :Samuel Martinez-Erro; Belén Martín-Matute; Franziska Schoenebeck; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Allylic substrates; Iridium catalysis; Base catalysis; Method development; Isomerization; Hydride shift; Proton shift; Mechanistic studies; organisk kemi; Organic Chemistry;

   Sammanfattning : The present thesis describes the development of new catalytic protocols to transform allylic substrates into a wide variety of versatile carbonyl and vinyl organic compounds. All procedures that are described in this work have in common the existence of one or more hydrogen shifts as key steps in the mechanism of the reactions. LÄS MER

4. 3. Asymmetric Synthesis and Mechanistic Studies on Copper(I)-Catalyzed Substitution of Allylic Substrates

   Författare :Jakob Norinder; Jan-Erling Bäckvall; Norbert Krause; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; copper; allylic substitution; ferrocene; DYKAT; cross-coupling; homo-coupling; DFT; Organic chemistry; Organisk kemi;

   Sammanfattning : This thesis deals with the copper-catalyzed substitution of allylic substrates.In the first part of this thesis, the synthesis of a series of metallocenethiolates is described. The thiolates were examined as ligands in the enantioselective copper(I)-catalyzed γ-substitution of allylic acetates. LÄS MER

5. 4. Copper and Palladium-Mediated Transformationsof Allylic and Propargylic Substrates

   Författare :Tony S. N. Zhao; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : This thesis is focused on the development of new palladium and copper-mediated reactions for functionalization of alkenes and propargylic alcohol derivatives. We have developed an efficient procedure for the synthesis of allenyl and propargyl boronate from propargylic carbonates and acetates. LÄS MER

7. 5. Catalytic Functionalization of Allylic Substrates by Palladium Pincer Complexes

   Författare :Nicklas Selander; Kálmán Szabó; David Milstein; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Catalysis; Palladium; Pincer Complex; Boron; Multicomponent Reaction; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis is based on the development of novel catalytic reactions for the synthesis and application of organometallic reagents. The main focus is directed towards organoboronate derivatives. We developed an efficient procedure for converting allylic alcohols to the corresponding allylboronates using palladium pincer complexes as catalysts. LÄS MER