Sökning: "Aleta Cebere"

Hittade 1 avhandling innehållade orden Aleta Cebere.

  1. 1. Effects of ethanol on NMDA receptor-mediated functions in primary cultures of cerebellar granule cells

    Författare :Aleta Cebere; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glutamate; NR2A and NR2B subunits; NMDA ethanol; homoquinolinic acid; glycine; spermidine; NMDA receptor antagonists; Ca 21; neurotoxicity; neuroprotection; AP-1; RT-PCR; Western blot; cerebellar granule cells;

    Sammanfattning : Primary cultures of cerebellar granule cells were used to investigate the effects of acute and chronic exposure of ethanol on NMDA receptor functions and to examine the possible sites of interaction between ethanol and the NMDA receptor. Activation of NMDA receptors induced elevation of free cytoplasmic Ca2+, Ca2+ influx, activation of protein kinase C and neurotoxicity. LÄS MER