Sökning: "Akt signaling"
Visar resultat 6 - 10 av 138 avhandlingar innehållade orden Akt signaling.
6. Regulation of Apoptosis in Hematopoietic Progenitor Cells: Involvement of Different Signaling Pathways
Sammanfattning : Proliferation, differentiation, and survival of hematopoietic stem cells and multipotent progenitor cells are regulated by cytokines and cell-cell interactions. Kit ligand (KL) and Flt3 ligand (FL) have pleiotropic effects, promotes survival, but are nonredundant. LÄS MER
7. Akt signaling and coordinated changes in the distribution and expression of Akt-regulating phosphatases
Sammanfattning : Cancer is one of the major causes of death worldwide. The PI3K/Akt signaling pathway is up-regulated in a variety of human cancers. Akt is an important signaling molecule in cellular survival pathways. Activated Akt (pAkt) is able to induce protein synthesis pathways, and is therefore a key protein involved in growth and prevention of apoptosis. LÄS MER
8. Regulation of intracellular signaling events that modulate insulin action
Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER
9. Molecular mechanisms for activation of non-canonical TGFβ pathways and their importance during prostate cancer progression
Sammanfattning : Prostate cancer is the most common invasive cancer diagnosed in men and a major and growing health problem in Western countries. Deregulation of different pathways has been implicated in progression of prostate cancer, namely nuclear factor kappa enhancer binding protein (NF-κB), transforming growth factor β (TGFβ), phosphoinositide 3ʹ-kinase/AKT (PI3K/AKT) and Src kinase pathways. LÄS MER
10. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation
Sammanfattning : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. LÄS MER