Sökning: "Akt signaling"

Visar resultat 1 - 5 av 123 avhandlingar innehållade orden Akt signaling.

  1. 1. Integrin Signaling in Cell Adhesion and Mechanotransduction Regulation of PI3K, AKT, and ROS

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Kathrin Stephanie Zeller; Uppsala universitet.; [2012]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; integrin; ROS; PI3K; AKT; mechanosignaling; actin polymerization; spreading;

    Sammanfattning : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. LÄS MER

  2. 2. From 1p3 to PI3K - Studies of neuroblastoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Susanne Fransson; Göteborgs universitet.; Gothenburg University.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; neuroblastoma; PI3K; PIK3CD; 1p36; alternative splicing; tumor; neural crest; mucosa; premalignant; tumor suppressor gene; oncogene; gene expression; epigenetics; splicing; signaling; akt; western blot; TaqMan; PIK3R1; p110H; p37H; p85; RAS;

    Sammanfattning : Neuroblastoma (NB) is a tumor of the sympathetic nervous system and is the most common extra-cranial tumor of childhood, accounting for 7% of all pediatric malignancies. Despite recent advances in therapeutics, outcome is still fatal for patients with aggressive NB and side-effects of treatment are severe. LÄS MER

  3. 3. Oncogenic ALK signaling in neuroblastoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ganesh Umapathy; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaplastic lymphoma kinase; neuroblastoma; ERK5; Akt; MYCN; mTOR;

    Sammanfattning : Over the last decade Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase (RTK) has been identified as a translocation partner in diverse cancer types. In tumors, where the full-length ALK RTK itself is mutated, such as neuroblastoma, the picture is less clear regarding ALKs role as an oncogenic driver. LÄS MER

  4. 4. Non-canonical TGFb signaling pathways in prostate cancer

    Detta är en avhandling från Umeå : Umeå University

    Författare :Jie Song; Umeå universitet.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGFβ; TβRI; TRAF6; ubiquitination; APPL1; p85; AKT; PKCζ;

    Sammanfattning : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. LÄS MER

  5. 5. Colorectal cancer and radiation response The role of EGFR, AKT and cancer stem cell markers

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Sara Häggblad Sahlberg; Uppsala universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; colorectal cancer; radiation; AKT; EGFR; cancer stem cells; CD133; CD44; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. LÄS MER