Sökning: "Akt PKB"

Visar resultat 21 - 22 av 22 avhandlingar innehållade orden Akt PKB.

  1. 21. Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats

    Författare :Jie Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Protein-tyrosine phosphatase; insulin; glucagon; vanadate; type 2 diabetes; pancreatic islets;

    Sammanfattning : Both insulin and glucagon secretion from pancreatic beta- and alpha-cells, respectively, are regulated by nutrients such as glucose and amino acids. In addition, the mechanisms leading to exocytosis of hormones are influenced by kinases and phosphatases that phosphorylate and dephosphorylate regulatory proteins respectively. LÄS MER

  3. 22. Mechanisms controlling midbrain dopaminergic neuron development

    Författare :Shanzheng Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. LÄS MER