Sökning: "Akt PKB"
Visar resultat 16 - 20 av 22 avhandlingar innehållade orden Akt PKB.
16. A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma
Sammanfattning : The present investigation is a multifaceted study of the receptor tyrosine kinase Axl, whose overexpression and activation is implicated in several human malignancies, with focus on renal cell carcinoma (RCC). At first, our main interest concerned the intracellular Axl interactor named Tensin2 (Tns2) and its family member Tensin3 (Tns3). LÄS MER
17. Microbe-induced apoptosis in phagocytic cells and its role in innate immunity
Sammanfattning : Apoptosis, or programmed cell death, is a controlled process by which aged or damages cells are eliminated in multicellular organisms. Neutrophils, short-lived phagocytes of the innate immune system, are highly equipped effectors that can sense, locate, ingest and kill bacterial pathogens. LÄS MER
18. Signal transduction in human phagocytic cells during phagocytosis, oxidative activation and apoptosis
Sammanfattning : Neutrophils and macrophages are professional phagocytic cells that play a crucial role in host defense against invading microorganisms. They bind to, internalize, and subsequently kill microbes with an arsenal of reactive oxygen metabolites and microbicidal agents. LÄS MER
19. Neuropeptides and neurotransmitters in keratocytes : importance in corneal wound healing processes
Sammanfattning : Background: The cornea is the outermost transparent layer of the eye and it is responsible for the majorityof the eye’s total focusing power. Keratocytes are the resident cells of the corneal stroma and their function isto produce extracellular matrix components and to take part in corneal healing after injury, which may occurdue to trauma, infection or surgery. LÄS MER
20. Insulin signalling in human adipocytes : mechanisms of insulin resistance in type 2 diabetes
Sammanfattning : Prevalensen av fetma ökar drastiskt i stora delar av världen och utgör en stor riskfaktor för att utveckla insulinresistens och typ 2 diabetes. Fettväven kan bli mycket stor om för mycket energi tas upp av kroppen. LÄS MER