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Visar resultat 1 - 5 av 22 avhandlingar som matchar ovanstående sökkriterier.
1. Hormone-Sensitive Lipase and Protein Kinase B; Molecular characterization in testis, adipose tissue and pancreatic beta cells
Sammanfattning : Hormone-sensitive lipase (HSL) and protein kinase B (PKB) are enzymes that in different ways are associated with lipid metabolism. While HSL is the well-known lipolytic enzyme responsible for hydrolysis of stored triacylglycerols in adipose tissue, PKB is a recently identified serine/threonine protein kinase, ubiquitously expressed and involved in signal transduction pathways induced by insulin and growth factors. LÄS MER
2. Mechanisms of survival and maintenance of Hematopoietic Stem Cells and Multipotent Progenitor Cells
Sammanfattning : Hematopoietic stem cells and progenitor cells are maintained in the bone marrow microenvironment, where factors including soluble and membrane-bound cytokines influence the processes of self-renewal, proliferation and differentiation. Two nonreduntant cytokines with effects on hematopoiesis, Kit Ligand (KL) and Flt3 Ligand (FL), signal via related tyrosine kinase receptors, c-kit and Flt3. LÄS MER
3. Mechanisms of Integrin Signal Transduction
Sammanfattning : Integrins are a protein family of cell surface receptors, expressed in all cell types in the human body, except the red blood cells. Besides their importance in mediating physical connections with the surrounding environment, the integrin family members are also vital signalling mediators. LÄS MER
4. PKB/Akt kinase localization and role in stemness maintenance in cancer
Sammanfattning : Cancer incidence rates have increased over the last decade. Currently available therapies are only moderately effective in targeting cancer cells. Established cancer treatment protocols fail to eliminate populations of cancer stem cells (CSCs), which develop resistance against the chemotherapeutic drugs and lead to cancer recurrence. LÄS MER
5. Molecular mechanisms of insulin resistance with special emphasis on IRS-1 and PKB/Akt
Sammanfattning : .... LÄS MER