Sökning: "Airway provocations"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Airway provocations.
1. The asthmatic airway response – effects on physiology and biomarkers
Sammanfattning : Asthma is a common airway inflammatory disease, associated with a variable degree of airway obstruction. It is a heterogeneous condition with large variations in severity and clinical presentation. Moreover, disease activity can vary from time to time. Taken together, these factors make the diagnosis, monitoring and treatment of asthma challenging. LÄS MER
2. Effects of Inflammatory Mediators on Pulmonary Airways
Sammanfattning : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. LÄS MER
3. Bronchoprovocation studies to define mechanisms in asthma and airway inflammation
Sammanfattning : Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In research, the bronchoprovocation model represents an excellent tool to better understand asthma pathophysiology, and to assess the effects of different interventions and new investigational therapies. LÄS MER
4. Studies of exercise-induced bronchoconstriction to define protective mechanisms in asthma
Sammanfattning : Exercise-induced bronchoconstriction (EIB) occurs in the majority of asthmatics following vigorous exercise. EIB is caused by a loss of water from the airways creating a hyperosmolar environment in the tissue that in turn triggers the release of bronchoconstrictive mediators. LÄS MER
5. The contribution of eosinophils and mediators in allergic inflammation
Sammanfattning : The aim of the present work was to investigate the development of allergic inflammation. For this purpose human experimental challenge models in skin, nose and bronchi were used as well as pharmacological interventions. A variety of inflammatory cells and mediators have been suggested as important in the pathogenesis of allergic inflammation. LÄS MER