Sökning: "Adverse drug reactions"

Visar resultat 21 - 25 av 76 avhandlingar innehållade orden Adverse drug reactions.

1. 21. Semantic Spaces of Clinical Text : Leveraging Distributional Semantics for Natural Language Processing of Electronic Health Records

   Författare :Aron Henriksson; Hercules Dalianis; Martin Duneld; Jussi Karlgren; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; distributional semantics; random indexing; semantic space; electronic health records; clinical text; synonyms; diagnosis codes; adverse drug reactions; Computer and Systems Sciences; data- och systemvetenskap; IT for health; IT för hälsa; datorlingvistik; Computational Linguistics; datalogi; Computer Science;

   Sammanfattning : The large amounts of clinical data generated by electronic health record systems are an underutilized resource, which, if tapped, has enormous potential to improve health care. Since the majority of this data is in the form of unstructured text, which is challenging to analyze computationally, there is a need for sophisticated clinical language processing methods. LÄS MER

3. 22. Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)

   Författare :Gunilla Englund; Per Artursson; Håkan Melhus; Andreas Kindmark; Joseph W Polli; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; membrane transport proteins; ATP-Binding Cassette Transporters; P-glycoprotein; Breast Cancer Resistance Protein; Interindividual variability; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Sammanfattning : The appearance of adverse drug reactions is a common reason for hospitalization in Western countries. Research on underlying biological mechanisms for interindividual variability in drug response aims to better identify patients with exceptional genetic traits, disease conditions or risk of drug-drug interactions and thereby help to prevent adverse drug reactions. LÄS MER

4. 23. Sex differences in adverse drug events from cardiovascular medicines in routine care

   Författare :Diana Rydberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In preventive drug treatment of cardiovascular disease, adverse drug effects often lead to suboptimal compliance with a risk of disability and shorter life expectancy. The overall aim of this thesis was to assess the nature and extent of adverse drug events (ADEs) from cardiovascular drugs in both women and men treated in routine care. LÄS MER

5. 24. CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions

   Författare :Staffan Rosenborg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20% of all drugs. All CYP2C enzymes are polymorphic, i.e. LÄS MER

7. 25. Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

   Författare :Khedidja Hedna; Staffan Hägg; Max Petzold; Katja Hakkarainen; Johan Fastbom; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug-related morbidity; medication adherence; inappropriate prescribing; elderly; drug utilisation; pharmacoepidemiology;

   Sammanfattning : Background: Inappropriate use of medications (IUM), in particular inappropriate prescribing and non-adherence to prescribed medications, are important causes of drug-related morbidities (DRMs). They are increasing problems with the ageing populations and the growing burden of chronic conditions. LÄS MER