Sökning: "Adverse drug reaction"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Adverse drug reaction.

1. 1. Spontaneous reporting of adverse drug reactions : Possibilities and limitations

   Författare :Martin Bäckström; Tom Mjörndal; Rune Dahlqvist; Folke Sjökvist; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; adverse drug reactions; spontaneous reporting; metamizole; general practitioners; hospital physicians; under-reporting; economical inducement; nurses.; Farmakologi; Pharmacological research; Farmakologisk forskning; Clinical Pharmacology; klinisk farmakologi;

   Sammanfattning : Adverse drug reactions (ADRs) constitute a major problem in society and in drug therapy. They are a common cause of short-term hospitalization, prolonged hospitalization and death. Spontaneous reporting of ADRs remains one the most effective methods for detecting new and serious drug reactions. LÄS MER

3. 2. Statistical methods for knowledge discovery in adverse drug reaction surveillance

   Författare :G. Niklas Norén; Rolf Sundberg; I. Ralph Edwards; Heikki Mannila; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mathematical statistics; Matematisk statistik; Mathematical Statistics; matematisk statistik;

   Sammanfattning : Collections of individual case safety reports are the main resource for early discovery of unknown adverse reactions to drugs once they have been introduced to the general public. The data sets involved are complex and based on voluntary submission of reports, but contain pieces of very important information. LÄS MER

4. 3. Drug treatment in children with focus on off-label drug use

   Författare :Elin Kimland; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Child; drug treatment; off-label; drug related problems; adverse drug reactions; drug labelling;

   Sammanfattning : There is a lack of paediatric documentation concerning efficacy and safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using different settings and design to evaluate pharmacological treatment in children, with focus on off-label drug use, is presented. LÄS MER

5. 4. Safety of Medication in Paediatrics

   Författare :Kristina Star; Karin Nordin; I Ralph Edwards; Richard Irvin Cook; Uppsala universitet; []
   Nyckelord :paediatrics; adverse drug reaction; drug-related problem; medication error; patient safety; individual case safety reports; pharmacovigilance; medication; nurses; health care personnel; dosage form; NSAID; dosing; prescription; antipsychotic medicines; postmarketing surveillance; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Background: In paediatrics, the limited documentation to guide medication, the lack of suitable dosage forms, and the continuous development in childhood present a scenario where safety of medication is a particular challenge.Aim: To explore reported adverse drug reactions (ADRs) and the challenges in prescribing and administering medicines in paediatrics, in order to identify and suggest areas needing international surveillance within medication safety and improvement in the clinical setting. LÄS MER

7. 5. Computational studies of photodynamic drugs, phototoxic reactions and drug design

   Författare :Klefah Abrahem Klefah Musa; Leif Eriksson; Nino Russo; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NSAIDs; fluoroquinolone; photodegradation; phototoxicity; drug design; DFT; TD-DFT; Biophysical chemistry; Biofysikalisk kemi; Chemistry; Kemi;

   Sammanfattning : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. LÄS MER