Sökning: "Advanced cancer"
Visar resultat 1 - 5 av 354 avhandlingar innehållade orden Advanced cancer.
1. Chemoradiation in Gastrointestinal Cancer
Sammanfattning : Locally advanced inextirpable gastrointestinal cancer has poor prognosis and is associated with high morbidity. One treatment option is to use radiotherapy, often combined with chemotherapy (chemoradiation), either as preoperative treatment to facilitate surgery or in the palliative setting to relieve symptoms. LÄS MER
2. Clinical Aspects of Hereditary Breast Cancer
Sammanfattning : A positive family history of breast cancer (BC) is one of the strongest predictors of the disease. Two major BC susceptibility genes, BRCA1 and BRCA2 were identified about a decade ago. In this thesis, studies of different biological. clinical and epidemiological aspects of hereditary BC are presented. LÄS MER
3. The extent of gynaecological cancer : Evaluation, outcome and quality of life
Sammanfattning : The overall aim of this thesis was to enhance treatment planning for gynaecological cancer patients and identify women that are more likely to have impaired quality of life (QoL) after treatment. In a retrospective cohort study on ovarian cancer, the peritoneal cancer index (PCI) was examined in relation to incomplete cytoreductive surgeries (CRS) and surgical complications (n=167). LÄS MER
4. Intratumoral CD40 stimulating therapy in patients with advanced cancer
Sammanfattning : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. LÄS MER
5. Trends in Prostate Cancer Mortality
Sammanfattning : In the early 20th century, cancer of the prostate was considered a rare and deadly disease with little to no possibility of cure. Since then, prostate cancer management has improved substantially with earlier detection, hormonal therapy, surgery and radiotherapy of the prostate. LÄS MER