Sökning: "Adipogenic differentiation"
Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Adipogenic differentiation.
1. The osteogenic potential of human mesenchymal stem cells: Novel markers and key factors for differentiation
Sammanfattning : Mesenchymal stem cells are multipotent stem cells with ability to differentiate into cells of the connective tissue lineage, such as adipocytes, osteoblasts and chondrocytes, both in vitro and in vivo. The main objective of the present thesis was to study different aspects of the osteogenic potential of MSCs. LÄS MER
2. Differentiation of Human Dermal Fibroblasts and Applications in Tissue Engineering
Sammanfattning : Tissue engineering applies principles of biology and engineering to the development of functional substitutes for damaged or lost tissues. Tools for the neo-generation of tissue in tissue engineering research include cells, biomaterials and soluble factors. LÄS MER
3. Fibroblast Differentiation and Models of Human Skin
Sammanfattning : This thesis combines three publications and one manuscript, covering two principal topics: functional differentiation of human fibroblasts and laboratory models of human skin. The two topics favourably unite in the realm of tissue engineering. This thesis is therefore split into three main parts: 1. LÄS MER
4. Pancreatic extracellular communication. Applications to beta cell cultures and islet amyloid polypeptide aggregation
Sammanfattning : Diabetes mellitus (DM) is a disease with epidemic proportions due to increased incidences worldwide, persistence of undiagnosed cases, uncontrolled forms of the disease, association with cardiovascular complications, and lack of definitive treatment options. In particular, type 2 DM (T2DM) is placing an enormous financial burden on worldwide healthcare systems that will increase in the futureThere is a need to develop physiological assay platforms that provide functionally relevant models of diabetes in order to accelerate the discovery of new treatments. LÄS MER
5. WISP-2 - A Novel Adipokine Related to Obesity and Insulin resistance
Sammanfattning : Type 2 diabetes mellitus (T2D) is increasing worldwide at an epidemic rate and is expected to reach 592 million inflicted individuals by 2035 as compared to 382 million in 2013. Obesity is a major risk factor for insulin resistance, defined as an impaired cellular effect of insulin, and this precedes the development of T2D. LÄS MER